Curcumin Protects BEAS‑2B Cells from PM‑induced Oxidative Stress and Inflammation by Activating NRF2/antioxidant Response Element Pathways

Overview

Journal Int J Mol Med

Specialty Genetics

Date 2021 Mar 3

PMID 33655321

Citations 7

Authors

Shuo Yang

Xiao-Long Huang

Jin Chen

Li-Na Mao

Xu Liu

Wen-Sheng Yuan

Xiao-Jie Wu

Guang-Wei Luo

Affiliations

Soon will be listed here.

Abstract

Fine particulate matter (PM) with an average aerodynamic diameter of <2.5 µm can cause severe lung injury. Oxidative stress and inflammation are considered the main outcomes of PM exposure. Curcumin is a well‑known antioxidant; however, its effect on PM‑induced oxidative injury in airway epithelial cells remains unclear. In the present study, it was demonstrated that pre‑treatment with curcumin significantly reduced the PM‑induced apoptosis of BEAS‑2B human bronchial epithelial cells by decreasing the level of intercellular reactive oxygen species. Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2‑related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes. Moreover, curcumin reduced the PM‑induced expression and production of inflammatory factors, and induced the expression of the anti‑inflammatory factors, interleukin (IL)‑5 and IL‑13. Taken together, the present study demonstrates that curcumin protects BEAS‑2B cells against PM‑induced oxidative damage and inflammation, and prevents cell apoptosis by increasing the activation of NRF2‑related pathways. It is thus suggested that curcumin may be a potential compound for use in the prevention of PM‑induced tissue injury.

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