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When MARCH Family Proteins Meet Viral Infections

Overview
Journal Virol J
Publisher Biomed Central
Specialty Microbiology
Date 2021 Mar 3
PMID 33653359
Citations 4
Authors
Affiliations
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Abstract

Membrane-associated RING-CH (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Recent studies have demonstrated that MARCH proteins play critical roles during various viral infections. MARCH proteins can directly antagonize different steps of the viral life cycle and promote individual viral infection. This mini-review will focus on the latest advances of MARCH family proteins' emerging roles during viral infections.

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References
1.
Bauer J, Bakke O, Morth J . Overview of the membrane-associated RING-CH (MARCH) E3 ligase family. N Biotechnol. 2016; 38(Pt A):7-15. DOI: 10.1016/j.nbt.2016.12.002. View

2.
Sun Z, Jha H, Pei Y, Robertson E . Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8. J Virol. 2016; 90(18):8047-58. PMC: 5008100. DOI: 10.1128/JVI.01079-16. View

3.
Nathan J, Sengupta S, Wood S, Admon A, Markson G, Sanderson C . The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic. 2008; 9(7):1130-45. PMC: 3761688. DOI: 10.1111/j.1600-0854.2008.00747.x. View

4.
Kreft S, Wang L, Hochstrasser M . Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem. 2005; 281(8):4646-53. DOI: 10.1074/jbc.M512215200. View

5.
Zhang Y, Lu J, Liu X . MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation. Virology. 2018; 518:293-300. DOI: 10.1016/j.virol.2018.02.003. View