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ZnT7 RNAi Favors Rafscrib-induced Tumor Growth and Invasion in Drosophila Through JNK Signaling Pathway

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Journal Oncogene
Date 2021 Mar 2
PMID 33649534
Citations 7
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Abstract

The disruption of zinc homeostasis has been identified in patients suffering from various cancers, but a causative relationship has not yet been established. Drosophila melanogaster has become a powerful model to study cancer biology. Here using a Drosophila model of malignant tumor Rafscrib, we observed that the tumor growth, invasion and migration were enhanced by silencing dZnT7, a zinc transporter localized on the Golgi apparatus. Further study indicated that the zinc deficiency in Golgi of dZnT7 RNAi resulted in ER stress which could activate the c-Jun-N-terminal Kinase (JNK) signaling and this process is mediated by Atg9. Lastly, we demonstrated that the exacerbation of dZnT7 RNAi on tumor was promoted by JNK signaling-dependent cell autonomous and non-autonomous autophagy. These findings suggest that zinc homeostasis in secretory compartments may provide a new therapeutic target for tumor treatment.

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References
1.
Kambe T, Tsuji T, Hashimoto A, Itsumura N . The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. Physiol Rev. 2015; 95(3):749-84. DOI: 10.1152/physrev.00035.2014. View

2.
McCall K, Huang C, Fierke C . Function and mechanism of zinc metalloenzymes. J Nutr. 2000; 130(5S Suppl):1437S-46S. DOI: 10.1093/jn/130.5.1437S. View

3.
Yan M, Song Y, Wong C, Hardin K, Ho E . Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr. 2008; 138(4):667-73. PMC: 4152237. DOI: 10.1093/jn/138.4.667. View

4.
Macdonald R . The role of zinc in growth and cell proliferation. J Nutr. 2000; 130(5S Suppl):1500S-8S. DOI: 10.1093/jn/130.5.1500S. View

5.
Hershfinkel M, Silverman W, Sekler I . The zinc sensing receptor, a link between zinc and cell signaling. Mol Med. 2007; 13(7-8):331-6. PMC: 1952663. DOI: 10.2119/2006-00038.Hershfinkel. View