ZnT7 RNAi Favors Rafscrib-induced Tumor Growth and Invasion in Drosophila Through JNK Signaling Pathway
Overview
Authors
Affiliations
The disruption of zinc homeostasis has been identified in patients suffering from various cancers, but a causative relationship has not yet been established. Drosophila melanogaster has become a powerful model to study cancer biology. Here using a Drosophila model of malignant tumor Rafscrib, we observed that the tumor growth, invasion and migration were enhanced by silencing dZnT7, a zinc transporter localized on the Golgi apparatus. Further study indicated that the zinc deficiency in Golgi of dZnT7 RNAi resulted in ER stress which could activate the c-Jun-N-terminal Kinase (JNK) signaling and this process is mediated by Atg9. Lastly, we demonstrated that the exacerbation of dZnT7 RNAi on tumor was promoted by JNK signaling-dependent cell autonomous and non-autonomous autophagy. These findings suggest that zinc homeostasis in secretory compartments may provide a new therapeutic target for tumor treatment.
Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM.
Yu W, Gui S, Xie J, Peng L, Xiao J, Luo H Aging (Albany NY). 2024; 16(4):3554-3582.
PMID: 38393693 PMC: 10929835. DOI: 10.18632/aging.205545.
Use-Dependent, Untapped Dual Kinase Signaling Localized in Brain Learning Circuitry.
Sears J, Broadie K J Neurosci. 2024; 44(12).
PMID: 38267256 PMC: 10957217. DOI: 10.1523/JNEUROSCI.1126-23.2024.
Chen B, Yu P, Chan W, Xie F, Zhang Y, Liang L Signal Transduct Target Ther. 2024; 9(1):6.
PMID: 38169461 PMC: 10761908. DOI: 10.1038/s41392-023-01679-y.
Fear-of-intimacy-mediated zinc transport is required for Drosophila fat body endoreplication.
Ji X, Gao J, Wei T, Jin L, Xiao G BMC Biol. 2023; 21(1):88.
PMID: 37069617 PMC: 10111752. DOI: 10.1186/s12915-023-01588-0.
Roles of in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Model.
Lee B, Choi B, Park Y, Jang S, Yuan C, Lim C Int J Mol Sci. 2022; 23(19).
PMID: 36233134 PMC: 9569493. DOI: 10.3390/ijms231911832.