The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland

Overview

Journal Nucl Med Mol Imaging

Publisher Springer

Date 2021 Mar 1

PMID 33643486

Authors

Andreas Lim

Hendra Budiawan

A Hussein S Kartamihardja

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to determine the influence of H2RAs to the 24-h I-131 uptake in the thyroid gland.

Material And Methods: A prospective study with quasi-experimental pre- and post-study design was done. Subjects with normal fT4 level who fulfilled the inclusion criteria were selected. All subjects received 0.2 mCi of I-131 orally, and the thyroid uptake calculations were performed at 24 h later. The same procedure was performed 4 weeks later. All of the subjects were asked to consume H2RAs 1 h before the administration of I-131 of the second procedure. Both 24-h thyroid uptakes were statistically analysed.

Results: A total of 14 subjects were enrolled in this study. Most of them were women (78%) with an average age of 37.6 years old (range: 20-55). This study showed a median of 24-h thyroid uptake of I-131 before and after H2-receptor antagonist of 20.6% (range: 11.1-57.8%) and 16.7% (range: 8.1-39.4%) respectively.

Conclusion: H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.

References

Yeong C, Cheng M, Ng K . Therapeutic radionuclides in nuclear medicine: current and future prospects. J Zhejiang Univ Sci B. 2014; 15(10):845-63. PMC: 4201313. DOI: 10.1631/jzus.B1400131. View

Corinaldesi R, Scarpignato C, Galassi A, Stanghellini V, Calamelli R, Bertaccini G . Effect of ranitidine and cimetidine on gastric emptying of a mixed meal in man. Int J Clin Pharmacol Ther Toxicol. 1984; 22(9):498-501. View

Means J . Historical background of the use of radioactive iodine in medicine. N Engl J Med. 1955; 252(22):936-40. DOI: 10.1056/NEJM195506022522204. View

Chung J . Sodium iodide symporter: its role in nuclear medicine. J Nucl Med. 2002; 43(9):1188-200. View

Silberstein E, Alavi A, Balon H, Clarke S, Divgi C, Gelfand M . The SNMMI practice guideline for therapy of thyroid disease with 131I 3.0. J Nucl Med. 2012; 53(10):1633-51. DOI: 10.2967/jnumed.112.105148. View

Edwards O, Yakish E, Wang L, Wu Q, Hoffman J, Morton K . Histamine Receptor 1 and 2 Antagonists Alter Biodistribution of Radioiodine. J Nucl Med Technol. 2015; 43(3):214-9. DOI: 10.2967/jnmt.115.160697. View

GRAYSON R . Factors which influence the radioactive iodine thyroidal uptake test. Am J Med. 1960; 28:397-415. DOI: 10.1016/0002-9343(60)90171-6. View

Becker D, Charkes N, DWORKIN H, Hurley J, McDougall I, Price D . Procedure guideline for thyroid uptake measurement: 1.0. Society of Nuclear Medicine. J Nucl Med. 1996; 37(7):1266-8. View

Forrest J, Heading R, Park J, Carter D, Lennon J, Lidgard G . Effect of histamine H2-receptor blockade on gastric emptying and serum gastrin in man. Scott Med J. 1976; 21(1):23-7. DOI: 10.1177/003693307602100107. View

10.

Bertaccini G, Coruzzi G . Cholinergic-like effects of the new histamine H2-receptor antagonist ranitidine. Agents Actions. 1982; 12(1-2):168-71. DOI: 10.1007/BF01965134. View

11.

Johansson L, Leide-Svegborn S, Mattsson S, Nosslin B . Biokinetics of iodide in man: refinement of current ICRP dosimetry models. Cancer Biother Radiopharm. 2003; 18(3):445-50. DOI: 10.1089/108497803322285206. View

12.

Nonaka T, Kessoku T, Ogawa Y, Imajyo K, Yanagisawa S, Shiba T . Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System). J Neurogastroenterol Motil. 2011; 17(3):287-93. PMC: 3155065. DOI: 10.5056/jnm.2011.17.3.287. View

13.

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View