» Articles » PMID: 3364045

[Comparative Morphine Determination in Parts of the Brain Using Combined Gas Chromatography/mass Spectrometry. A Possibility for Assessing Survival Time]

Overview
Journal Z Rechtsmed
Specialty Forensic Sciences
Date 1988 Jan 1
PMID 3364045
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Comparison of the morphine concentrations in the medulla oblongata and the cerebellum provides information on the interval between morphine administration and death. If this period is short, the ratio of CMed:CCereb is below 1. The ratio is above 1 if a number of hours have passed at least. The balance of the morphine concentrations is achieved within a few hours. Results have been achieved by gas chromatography/mass spectrometry analysis in about 100 autopsy cases.

Citing Articles

Aspiration in lethal drug abuse-a consequence of opioid intoxication.

Nicolakis J, Gmeiner G, Reiter C, Seltenhammer M Int J Legal Med. 2020; 134(6):2121-2132.

PMID: 32929594 PMC: 7578170. DOI: 10.1007/s00414-020-02412-y.


Micromorphological changes in cardiac tissue of drug-related deaths with emphasis on chronic illicit opioid abuse.

Seltenhammer M, Marchart K, Paula P, Kordina N, Klupp N, Schneider B Addiction. 2013; 108(7):1287-95.

PMID: 23297783 PMC: 3746107. DOI: 10.1111/add.12106.


Morphine in postmortem blood: its importance for the diagnosis of deaths associated with opiate addiction.

Staub C, Jeanmonod R, FRYC O Int J Legal Med. 1990; 104(1):39-42.

PMID: 11453091 DOI: 10.1007/BF01816482.


Postmortem distribution pattern of morphine and morphine glucuronides in heroin overdose.

Skopp G, Lutz R, Ganssmann B, Mattern R, Aderjan R Int J Legal Med. 1996; 109(3):118-24.

PMID: 8956984 DOI: 10.1007/BF01369670.

References
1.
Maurer R, Cortes R, Probst A, Palacios J . Multiple opiate receptor in human brain: an autoradiographic investigation. Life Sci. 1983; 33 Suppl 1:231-4. DOI: 10.1016/0024-3205(83)90485-x. View

2.
Vycudilik W . [The determination of barbiturates in biological matter]. Beitr Gerichtl Med. 1977; 35:213-20. View

3.
Pare E, Monforte J, Thibert R . Morphine concentrations in brain tissue from heroin-associated deaths. J Anal Toxicol. 1984; 8(5):213-6. DOI: 10.1093/jat/8.5.213. View

4.
Mullis K, Perry D, Finn A, Stafford B, Sadee W . Morphine persistence in rat brain and serum after single doses. J Pharmacol Exp Ther. 1979; 208(2):228-31. View

5.
Drost R, van Ooijen R, Ionescu T, Maes R . Determination of morphine in serum and cerebrospinal fluid by gas chromatography and selected ion monitoring after reversed-phase column extraction. J Chromatogr. 1984; 310(1):193-8. DOI: 10.1016/0378-4347(84)80081-x. View