In Silico Screening and Identification of Deleterious Missense SNPs Along with Their Effects on CD-209 Gene: An Insight to CD-209 Related-diseases

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Feb 26

PMID 33635927

Citations 8

Authors

Mohib Ullah Kakar

Muhammad Matloob

Rongji Dai

Yulin Deng

Kifayat Ullah

Ihsan Ullah Kakar

Ghulam Khaliq

Muhammad Umer

Zhoaib Ahmed Bhutto

Sarfarz Ali Fazlani

Muhammad Zubair Mehboob

Affiliations

Soon will be listed here.

Abstract

DC-SIGN receptor articulated by macrophages and dendritic cells is encoded by CD209 gene and plays a role to activate and proliferate the T-lymphocytes in response of virus attack. The dysfunctional activity of DC-SIGN receptor because of missense SNPs can lead to cause dengue haemorrhage fever, HIV-1 infection etc. Out of 11 transcripts of CD209, all missense SNPs of canonical transcript were retrieved from Ensembl database and evaluated by their deleteriousness by using Polyphen-2, PMut, SIFT, MutPred, PROVEAN and PhD-SNP together with stimulation of its complete 3D structure. 10 nsSNPs were chosen depending on both the significance value of nsSNP and their prediction among SNPs evaluating servers which are based on different algorithms. Moreover, the position and native role of 10 nsSNPs in wild 3D model has been described which assist to acknowledge their importance. This study urges the researcher's community to experimentally validate these SNPs and their association in causing the diseases like dengue fever, Tuberculosis etc.

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