Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies
Overview
Affiliations
Impulse control disorders (ICDs) in Parkinson's disease (PD) are aberrant behavior such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically occur as a result of dopaminergic therapy. Numerous studies have focused on the broad spectrum of ICDs-related behaviors and their tremendous impact on patients and their family members. Recent advances have improved our understanding of ICDs. In this review, we discuss the epidemiology, pathogenesis and treatment of ICDs in the setting of PD.
Impulse control disorders in Parkinson's disease: What's new?.
Marques A, Lewis S J Neurol. 2025; 272(2):138.
PMID: 39812828 DOI: 10.1007/s00415-024-12865-5.
APOE contributes to longitudinal impulse control disorders progression in Parkinson's disease.
Chen L, He X, Mao L, Liu P BMC Psychiatry. 2024; 24(1):632.
PMID: 39334114 PMC: 11438395. DOI: 10.1186/s12888-024-06084-5.
Zhao J, Wang J, Zhao K, Yang S, Dong J, Zhang Y Mol Neurobiol. 2024; 62(2):2250-2263.
PMID: 39096445 PMC: 11772544. DOI: 10.1007/s12035-024-04367-2.
Rats Lacking the Dopamine Transporter Display Inflexibility in Innate and Learned Behavior.
Belskaya A, Kurzina N, Savchenko A, Sukhanov I, Gromova A, Gainetdinov R Biomedicines. 2024; 12(6).
PMID: 38927477 PMC: 11200708. DOI: 10.3390/biomedicines12061270.
Tos M, Grazynska A, Antoniuk S, Siuda J Brain Sci. 2024; 14(2).
PMID: 38391755 PMC: 10886884. DOI: 10.3390/brainsci14020181.