Interaction of Plasmodium Falciparum Apicortin with α- and β-tubulin is Critical for Parasite Growth and Survival

Overview

Journal Sci Rep

Specialty Science

Date 2021 Feb 26

PMID 33633135

Citations 7

Authors

Malabika Chakrabarti

Nishant Joshi

Geeta Kumari

Preeti Singh

Rumaisha Shoaib

Akshay Munjal

Vikash Kumar

Ankita Behl

Mohammad Abid

Swati Garg

Sonal Gupta

Shailja Singh

Affiliations

Soon will be listed here.

Abstract

Cytoskeletal structures of Apicomplexan parasites are important for parasite replication, motility, invasion to the host cell and survival. Apicortin, an Apicomplexan specific protein appears to be a crucial factor in maintaining stability of the parasite cytoskeletal assemblies. However, the function of apicortin, in terms of interaction with microtubules still remains elusive. Herein, we have attempted to elucidate the function of Plasmodium falciparum apicortin by monitoring its interaction with two main components of parasite microtubular structure, α-tubulin-I and β-tubulin through in silico and in vitro studies. Further, a p25 domain binding generic drug Tamoxifen (TMX), was used to disrupt PfApicortin-tubulin interactions which led to the inhibition in growth and progression of blood stage life cycle of P. falciparum.

Citing Articles

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