Article: Open science takes on Parkinson's disease

The Aligning Science Across Parkinson's (ASAP) initiative was set up to improve understanding of the biology underlying the onset and progression of Parkinson's disease. With an emphasis on open science and collaboration, we have assembled a research network led by nearly 100 investigators to explore the pathology of Parkinson's disease, and this network will soon expand to include researchers working on relevant (dys)-functional neural circuits. We have also contributed to large-scale genetics and patient cohort initiatives related to the disease. We hope that these actions, and others planned for the future, will deepen our knowledge of the molecular mechanisms underlying the origin and evolution of Parkinson's disease and, ultimately, contribute to the development of novel therapies.

Citing Articles

From policy to practice: Lessons learned from an open science funding initiative.

Dumanis S, Ratan K, McIntosh S, Shah H, Lewis M, Vines T PLoS Comput Biol. 2023; 19(12):e1011626.

PMID: 38060981 PMC: 10703508. DOI: 10.1371/journal.pcbi.1011626.

Clinical trials for cognition in Parkinson's disease: Where are we and how can we do better?.

Bayram E, Batzu L, Tilley B, Gandhi R, Jagota P, Biundo R Parkinsonism Relat Disord. 2023; 112:105385.

PMID: 37031010 PMC: 10330317. DOI: 10.1016/j.parkreldis.2023.105385.

Black and African American Connections to Parkinson's Disease Study: Addressing Missing Diversity in Parkinson's Disease Genetics.

Bandres-Ciga S Mov Disord. 2022; 37(7):1559-1561.

PMID: 35488798 PMC: 9348590. DOI: 10.1002/mds.29042.

Multi-modality machine learning predicting Parkinson's disease.

Makarious M, Leonard H, Vitale D, Iwaki H, Sargent L, Dadu A NPJ Parkinsons Dis. 2022; 8(1):35.

PMID: 35365675 PMC: 8975993. DOI: 10.1038/s41531-022-00288-w.

Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms.

Schilder B, Navarro E, Raj T Neurobiol Dis. 2021; 163:105580.

PMID: 34871738 PMC: 10101343. DOI: 10.1016/j.nbd.2021.105580.

References

1.

Hall K, Vogel A, Huang G, Serrano K, Rice E, Tsakraklides S . The science of team science: A review of the empirical evidence and research gaps on collaboration in science. Am Psychol. 2018; 73(4):532-548. DOI: 10.1037/amp0000319. View

2.

Nalls M, Blauwendraat C, Vallerga C, Heilbron K, Bandres-Ciga S, Chang D . Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 2019; 18(12):1091-1102. PMC: 8422160. DOI: 10.1016/S1474-4422(19)30320-5. View

3.

Schekman R, Riley E . Coordinating a new approach to basic research into Parkinson's disease. Elife. 2019; 8. PMC: 6760967. DOI: 10.7554/eLife.51167. View

4.

Tripodi G, Chiaromonte F, Lillo F . Knowledge and social relatedness shape research portfolio diversification. Sci Rep. 2020; 10(1):14232. PMC: 7455750. DOI: 10.1038/s41598-020-71009-7. View

5.

Chen-Plotkin A, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D . Finding useful biomarkers for Parkinson's disease. Sci Transl Med. 2018; 10(454). PMC: 6097233. DOI: 10.1126/scitranslmed.aam6003. View

Open Science Takes on Parkinson's Disease