The Clinical Efficacy of Phytochemical Medicines Containing Tanshinol and Ligustrazine in the Treatment of Stable Angina: A Systematic Review and Meta-Analysis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2021 Feb 24

PMID 33623530

Citations 1

Authors

Li Gao

Tong Wu

Juan Wang

Zhuoran Xiao

Chunhua Jia

Wei Wang

Affiliations

Soon will be listed here.

Abstract

Background: Phytochemical medicines containing tanshinol and ligustrazine are commonly used in the treatment of stable angina in China, but their clinical effectiveness and risk have not been adequately assessed. In this paper, we conducted a systematic review and meta-analysis to evaluate the clinical efficacy.

Methods: Relevant randomized controlled trials (RCTs) of phytochemical medicines containing tanshinol and ligustrazine in the treatment of stable angina were searched in electronic databases. The search date was up to March 31, 2020, and the languages of the RCTs were limited to English and Chinese.

Results: A total of 28 studies, including 2518 patients, were included in the meta-analysis. It was shown that the adjunctive therapy of phytochemical medicines containing tanshinol and ligustrazine was better than the conventional therapies in the improvement of stable angina according to the clinical efficacy in symptoms ( = 2518, RR = 1.24, 95% CI: 1.20 to 1.29, < 0.01) and clinical efficacy in electrocardiography ( = 1766, RR = 1.29, 95% CI: 1.19 to 1.40, < 0.01).

Conclusion: The meta-analysis supported the use of phytochemical medicines containing tanshinol and ligustrazine in the treatment of stable angina. However, quality of the evidence for this finding was low due to a high risk of bias in the included studies. Therefore, well-designed RCTs are still needed to further evaluate the efficacy.

Citing Articles

Mechanism and Potential Target of Blood-Activating Chinese Botanical Drugs Combined With Anti-Platelet Drugs: Prevention and Treatment of Atherosclerotic Cardiovascular Diseases.

Li D, Li Y, Yang S, Yu Z, Xing Y, Wu M Front Pharmacol. 2022; 13:811422.

PMID: 35721128 PMC: 9204194. DOI: 10.3389/fphar.2022.811422.

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