Effectiveness of Self-assembling Peptide P-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A Clinical Randomized Trial

Overview

Journal Int J Clin Pediatr Dent

Specialty Pediatrics

Date 2021 Feb 24

PMID 33623327

Citations 10

Authors

Riham Kobeissi

Sherine By Badr

Essam Osman

Affiliations

Soon will be listed here.

Abstract

Background: Fluoride varnish with therapeutic tricalcium phosphate formulas such as Clinpro™ varnish has shown greater tendency in treating white spot lesions (WSLs) by inhibiting the progression of initial enamel lesions through the mineral exchange. The self-assembling peptide SAP-4 (Curodont Repair, CDR) works on a different scale in treating WSLs by mimicking the enamel matrix and aiming to guided enamel regeneration.

Aim: To quantitatively and qualitatively compare the effectiveness of the SAP-4 vs tricalcium posphate fluoride (TCPF) in remineralization of WSLs in young permanent teeth.

Materials And Methods: Nine healthy patients were enrolled in this study. The trial was performed on 40 young permanent teeth in the initial demineralization stage. Teeth were randomly assigned to receive either TCPF (group I) or SAP-4 (group II). Lesions were assessed at pretreatment, 3, and 6 months posttreatment quantitatively per laser fluorescence DIAGNOdent pen and qualitatively through the International Caries Detection and Assessment System (ICDAS) II.

Results: The result of the current study revealed a significant quantitative and qualitative increase in remineralization of WSLs in both groups and over time intervals. However, the WSL recovery was significantly better in the self-assembling peptide group, reflecting an excellent remineralization potential of the WSLs by the SAP-4 compared to TCPF varnish.

Conclusion: Both TCPF and SAP-4 were effective in treating WSLs. However, the success of guided enamel regeneration by the SAP-4 through the biomineralization has proven superiority of this material compared to TCPF.

Clinical Significance: Early detection of WSLs and minimal intervention through remineralizing agents can limit unnecessary tissue loss, further caries progression, and consequently prevent further harm to the patients.

How To Cite This Article: Kobeissi R, Badr SBY, Osman E. Effectiveness of Self-assembling Peptide P-4 Compared to Tricalcium Phosphate Fluoride Varnish in remineralization of White Spot Lesions: A Clinical Randomized Trial. Int J Clin Pediatr Dent 2020;13(5):451-456.

Citing Articles

White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.

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Evaluation of the effect of self-assembling peptide and fluoride varnish, alone or in combination with laser irradiation, on artificial enamel caries: a SEM/EDS and Micro-CT study.

Asik A, Oncag O Clin Oral Investig. 2024; 28(9):503.

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Evaluation of the remineralization potential of self-assembling peptide P11-4 with fluoride compared to fluoride varnish in the management of incipient carious lesions: a randomized controlled clinical trial.

Shaalan O, Fawzy El-Sayed K, Abouauf E Clin Oral Investig. 2024; 28(8):438.

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Biomimetic Enamel Regeneration Using Self-Assembling Peptide P-4.

Alkilzy M, Qadri G, Splieth C, Santamaria R Biomimetics (Basel). 2023; 8(3).

PMID: 37504178 PMC: 10807035. DOI: 10.3390/biomimetics8030290.

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.

Xie Z, Yu L, Li S, Li J, Liu Y BMC Oral Health. 2023; 23(1):346.

PMID: 37264364 PMC: 10233982. DOI: 10.1186/s12903-023-03076-x.

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