Rational Design of Smart Hydrogels for Biomedical Applications

Overview

Journal Front Chem

Specialty Chemistry

Date 2021 Feb 22

PMID 33614595

Citations 38

Authors

Yanyu Zhang

Yishun Huang

Affiliations

Soon will be listed here.

Abstract

Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host-guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

Citing Articles

Effects of Hydroxyapatite Additions on Alginate Gelation Kinetics During Cross-Linking.

Dimic-Misic K, Imani M, Gasik M Polymers (Basel). 2025; 17(2).

PMID: 39861314 PMC: 11768125. DOI: 10.3390/polym17020242.

Tumor cell membrane-based vaccines: A potential boost for cancer immunotherapy.

Yang M, Zhou J, Lu L, Deng D, Huang J, Tang Z Exploration (Beijing). 2024; 4(6):20230171.

PMID: 39713208 PMC: 11655317. DOI: 10.1002/EXP.20230171.

Regenerative medicine: Hydrogels and mesoporous silica nanoparticles.

Pablos J, Lozano D, Manzano M, Vallet-Regi M Mater Today Bio. 2024; 29:101342.

PMID: 39649249 PMC: 11625165. DOI: 10.1016/j.mtbio.2024.101342.

Poly(Vinyl Alcohol) Drug and PVA-Drug-Surfactant Complex Organogel with Dimethyl Sulfoxide as a Drug Delivery System.

Otarbayeva S, Berillo D Gels. 2024; 10(11).

PMID: 39590109 PMC: 11593573. DOI: 10.3390/gels10110753.

Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry.

Fratila D, Virvescu D, Luchian I, Hancianu M, Baciu E, Butnaru O Gels. 2024; 10(10).

PMID: 39451314 PMC: 11507597. DOI: 10.3390/gels10100661.

References

Xu W, Huang Y, Zhao H, Li P, Liu G, Li J . DNA Hydrogel with Tunable pH-Responsive Properties Produced by Rolling Circle Amplification. Chemistry. 2017; 23(72):18276-18281. DOI: 10.1002/chem.201704390. View

Walker B, Portillo Lara R, Mogadam E, Yu C, Kimball W, Annabi N . Rational Design of Microfabricated Electroconductive Hydrogels for Biomedical Applications. Prog Polym Sci. 2020; 92:135-157. PMC: 7441850. DOI: 10.1016/j.progpolymsci.2019.02.007. View

Palmese L, Thapa R, Sullivan M, Kiick K . Hybrid hydrogels for biomedical applications. Curr Opin Chem Eng. 2019; 24:143-157. PMC: 6914224. DOI: 10.1016/j.coche.2019.02.010. View

De Leon Rodriguez L, Hemar Y, Cornish J, Brimble M . Structure-mechanical property correlations of hydrogel forming β-sheet peptides. Chem Soc Rev. 2016; 45(17):4797-824. DOI: 10.1039/c5cs00941c. View

Almoshari Y, Ren R, Zhang H, Jia Z, Wei X, Chen N . GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis. Biomaterials. 2020; 261:120293. PMC: 7541605. DOI: 10.1016/j.biomaterials.2020.120293. View

Hao T, Li J, Yao F, Dong D, Wang Y, Yang B . Injectable Fullerenol/Alginate Hydrogel for Suppression of Oxidative Stress Damage in Brown Adipose-Derived Stem Cells and Cardiac Repair. ACS Nano. 2017; 11(6):5474-5488. DOI: 10.1021/acsnano.7b00221. View

Kamoun E, Kenawy E, Chen X . A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res. 2017; 8(3):217-233. PMC: 5315442. DOI: 10.1016/j.jare.2017.01.005. View

Fedele C, Netti P, Cavalli S . Azobenzene-based polymers: emerging applications as cell culture platforms. Biomater Sci. 2018; 6(5):990-995. DOI: 10.1039/c8bm00019k. View

Yuan P, Yang T, Liu T, Yu X, Bai Y, Zhang Y . Nanocomposite hydrogel with NIR/magnet/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy. Biomaterials. 2020; 262:120357. DOI: 10.1016/j.biomaterials.2020.120357. View

10.

Zhang S, Xin P, Ou Q, Hollett G, Gu Z, Wu J . Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery. J Mater Chem B. 2020; 6(42):6723-6730. DOI: 10.1039/c8tb01466c. View

11.

Zhu Y, Matsumura Y, Velayutham M, Foley L, Hitchens T, Wagner W . Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection. Biomaterials. 2018; 177:98-112. DOI: 10.1016/j.biomaterials.2018.05.044. View

12.

Cheng E, Xing Y, Chen P, Yang Y, Sun Y, Zhou D . A pH-triggered, fast-responding DNA hydrogel. Angew Chem Int Ed Engl. 2009; 48(41):7660-3. DOI: 10.1002/anie.200902538. View

13.

Tresoldi C, Pacheco D, Formenti E, Pellegata A, Mantero S, Petrini P . Shear-resistant hydrogels to control permeability of porous tubular scaffolds in vascular tissue engineering. Mater Sci Eng C Mater Biol Appl. 2019; 105:110035. DOI: 10.1016/j.msec.2019.110035. View

14.

Fan D, Tian Y, Liu Z . Injectable Hydrogels for Localized Cancer Therapy. Front Chem. 2019; 7:675. PMC: 6797556. DOI: 10.3389/fchem.2019.00675. View

15.

Pandit A, Mazumdar N, Ahmad S . Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications. Int J Biol Macromol. 2019; 137:853-869. DOI: 10.1016/j.ijbiomac.2019.07.014. View

16.

Lu C, Guo W, Hu Y, Qi X, Willner I . Multitriggered Shape-Memory Acrylamide-DNA Hydrogels. J Am Chem Soc. 2015; 137(50):15723-31. DOI: 10.1021/jacs.5b06510. View

17.

Lin C, Anseth K . PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res. 2008; 26(3):631-43. PMC: 5892412. DOI: 10.1007/s11095-008-9801-2. View

18.

Wang W, Narain R, Zeng H . Rational Design of Self-Healing Tough Hydrogels: A Mini Review. Front Chem. 2018; 6:497. PMC: 6232908. DOI: 10.3389/fchem.2018.00497. View

19.

Cambria E, Brunner S, Heusser S, Fisch P, Hitzl W, Ferguson S . Cell-Laden Agarose-Collagen Composite Hydrogels for Mechanotransduction Studies. Front Bioeng Biotechnol. 2020; 8:346. PMC: 7186378. DOI: 10.3389/fbioe.2020.00346. View

20.

Wang Y, Zhang Y, Li X, Li C, Yang Z, Wang L . A Peptide-Based Supramolecular Hydrogel for Controlled Delivery of Amine Drugs. Chem Asian J. 2018; 13(22):3460-3463. DOI: 10.1002/asia.201800708. View