Identification of Primary and Metastatic Lung Cancer-Related LncRNAs and Potential Targeted Drugs Based on CeRNA Network

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Feb 22

PMID 33614509

Citations 6

Authors

Siyao Dong

Cheng Wu

Chengyan Song

Baocui Qi

Lu Liu

Yan Xu

Affiliations

Soon will be listed here.

Abstract

Lung cancer metastasis is the leading cause of poor prognosis and death for patients. Long noncoding RNAs (lncRNAs) have been validated the close correlation with lung cancer metastasis, but few comprehensive analyses have reported the specific association between lncRNA and cancer metastasis, especially both competing endogenous RNA (ceRNA) regulatory relationships and functional regulatory networks. Here, we constructed primary and metastatic ceRNA networks, identified 12 and 3 candidate lncRNAs for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) respectively and excavated some drugs that might have potential therapeutic effects on lung cancer progression. In summary, this study systematically analyzed the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided a new idea for screening potential therapeutic drugs for lung cancer.

Citing Articles

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