Oncogenic ZEB2/miR-637/HMGA1 Signaling Axis Targeting Vimentin Promotes the Malignant Phenotype of Glioma

Overview

Journal Mol Ther Nucleic Acids

Publisher Cell Press

Date 2021 Feb 22

PMID 33614228

Citations 11

Authors

Yu Zeng

Tianshi Que

Jie Lin

Zhengming Zhan

Anqi Xu

Zhiyong Wu

Cheng Xie

Jie Luo

Shengfeng Ding

Hao Long

Xian Zhang

Ye Song

Affiliations

Soon will be listed here.

Abstract

Glioma is the most common primary tumor of the central nervous system. We previously confirmed that zinc finger E-box binding homeobox (ZEB) 2 promotes the malignant progression of glioma, while microRNA-637 (miR-637) is associated with favorable prognosis in glioma. This study aimed to investigate the potential interaction between ZEB2 and miR-637 and its downstream signaling pathway in glioma. The results revealed that ZEB2 could directly bind to the E-box elements in the miR-637 promoter and promote cell proliferation, migration, and invasion via miR-637 downregulation. Subsequent screening confirmed that HMGA1 was a direct target of miR-637, while miR-637 could drive the malignant phenotype of glioma by suppressing HMGA1 both and . Furthermore, interaction between cytoplasmic HMGA1 and vimentin was observed, and vimentin inhibition could abolish increased migration and invasion induced by HMGA1 overexpression. Both HMGA1 and vimentin were associated with an unfavorable prognosis in glioma. Additionally, upregulated HMGA1 and vimentin were found in isocitrate dehydrogenase (IDH) wild-type and 1p/19q non-codeletion diffusely infiltrating glioma. In conclusion, we identified an oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin that promotes both migration and invasion in glioma.

Citing Articles

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