Update: Innate Lymphoid Cells in Inflammatory Bowel Disease

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2021 Feb 20

PMID 33609209

Citations 25

Authors

Weiwei Luo

Li Tian

Bei Tan

Zhaohua Shen

Mengwei Xiao

Shuai Wu

Xiangrui Meng

Xing Wu

Xiaoyan Wang

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) is a chronic and nonspecific intestinal inflammatory condition with high relapse rate. Its pathogenesis has been linked to dysbacteriosis, genetic and environmental factors. In recent years, a new type of lymphocytes, termed innate lymphoid cells, has been described and classified into three subtypes of innate lymphoid cells-group 1, group 2 and group 3. An imbalance among these subsets' interaction with gut microbiome, and other immune cells affects intestinal mucosal homeostasis. Understanding the role of innate lymphoid cells may provide ideas for developing novel and targeted approaches for treatment of IBD.

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