Obesity, Type 2 Diabetes, and Cancer Risk

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Feb 19

PMID 33604295

Citations 75

Authors

Tiffany Scully

Abora Ettela

Derek LeRoith

Emily Jane Gallagher

Affiliations

Soon will be listed here.

Abstract

Obesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and have been implicated in the obesity-cancer relationship. Multiple mechanisms have been proposed to link obesity and diabetes with cancer progression, including an increase in insulin/IGF-1 signaling, lipid and glucose uptake and metabolism, alterations in the profile of cytokines, chemokines, and adipokines, as well as changes in the adipose tissue directly adjacent to the cancer sites. This review aims to summarize and provide an update on the epidemiological and mechanistic evidence linking obesity and type 2 diabetes with cancer, focusing on the roles of insulin, lipids, and adipose tissue.

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