Hyperpolarised Gas Filling Station for Medical Imaging Using Polarised Xe and He

Overview

Journal Magn Reson Imaging

Publisher Elsevier

Specialty Radiology

Date 2021 Feb 18

PMID 33600894

Authors

Wai Tung Lee

Gang Zheng

Cavin L Talbot

Xin Tong

Tim DAdam

Steven R Parnell

Michael de Veer

Graham Jenkin

Graeme R Polglase

Stuart B Hooper

Bruce R Thompson

Francis Thien

Gary F Egan

Affiliations

Soon will be listed here.

Abstract

We report the design, construction, and initial tests of a hyperpolariser to produce polarised Xe and He gas for medical imaging of the lung. The hyperpolariser uses the Spin-Exchange Optical Pumping method to polarise the nuclear spins of the isotopic gas. Batch mode operation was chosen for the design to produce polarised Xe and polarised He. Two-side pumping, electrical heating and a piston to transfer the polarised gas were some of the implemented techniques that are not commonly used in hyperpolariser designs. We have carried out magnetic resonance imaging experiments demonstrating that the He and Xe polarisation reached were sufficient for imaging, in particular for in vivo lung imaging using Xe. Further improvements to the hyperpolariser have also been discussed.

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