Disruptions in Oral and Nasal Microbiota in Biomass and Tobacco Smoke Associated Chronic Obstructive Pulmonary Disease

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 2021 Feb 18

PMID 33598807

Citations 8

Authors

Dhiraj M Agarwal

Dhiraj P Dhotre

Shreyas V Kumbhare

Akshay H Gaike

Bill B Brashier

Yogesh S Shouche

Sanjay K Juvekar

Sundeep S Salvi

Affiliations

Soon will be listed here.

Abstract

Chronic exposures to tobacco and biomass smoke are the most prevalent risk factors for COPD development. Although microbial diversity in tobacco smoke-associated COPD (TSCOPD) has been investigated, microbiota in biomass smoke-associated COPD (BMSCOPD) is still unexplored. We aimed to compare the nasal and oral microbiota between healthy, TSCOPD, and BMSCOPD subjects from a rural population in India. Nasal swabs and oral washings were collected from healthy (n = 10), TSCOPD (n = 11), and BMSCOPD (n = 10) subjects. The downstream analysis was performed using QIIME pipeline (v1.9). In nasal and oral microbiota no overall differences were noted, but there were key taxa that had differential abundance in either Healthy vs COPD and/or TSCOPD vs. BMSCOPD. Genera such as Actinomyces, Actinobacillus, Megasphaera, Selenomonas, and Corynebacterium were significantly higher in COPD subjects. This study suggests that microbial community undergoes dysbiosis which may further contribute to the progression of disease. Thus, it is important to identify etiological agents for such a polymicrobial alterations which contribute highly to the disease manifestation.

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