Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Feb 18

PMID 33597928

Citations 42

Authors

Livia Odagiu

Julia May

Salix Boulet

Troy A Baldwin

Nathalie Labrecque

Affiliations

Soon will be listed here.

Abstract

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated their expression levels. Their expression is transiently induced in T cells by triggering of the T cell receptor following antigen recognition during both thymic differentiation and peripheral T cell responses. In this review, we will discuss how NR4A family members impact different aspects of the life of a T cell from thymic differentiation to peripheral response against infections and cancer.

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