Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 2021 Feb 17

PMID 33595806

Citations 7

Authors

Lily Wan

Du Liu

Wen-Biao Xiao

Bo-Xin Zhang

Xiao-Xin Yan

Zhao-Hui Luo

Bo Xiao

Affiliations

Soon will be listed here.

Abstract

The Shank family proteins are enriched at the postsynaptic density (PSD) of excitatory glutamatergic synapses. They serve as synaptic scaffolding proteins and appear to play a critical role in the formation, maintenance and functioning of synapse. Increasing evidence from genetic association and animal model studies indicates a connection of SHANK genes defects with the development of neuropsychiatric disorders. In this review, we first update the current understanding of the SHANK family genes and their encoded protein products. We then denote the literature relating their alterations to the risk of neuropsychiatric diseases. We further review evidence from animal models that provided molecular insights into the biological as well as pathogenic roles of Shank proteins in synapses, and the potential relationship to the development of abnormal neurobehavioral phenotypes.

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