Contribution of P2X4 Receptor in Pain Associated with Rheumatoid Arthritis: a Review

Overview

Journal Purinergic Signal

Publisher Springer

Date 2021 Feb 17

PMID 33594635

Citations 7

Authors

Nurul Ajilah Mohamed Khir

Ain Sabreena Mohd Noh

Nazlahshaniza Shafin

Che Aishah Nazariah Ismail

Affiliations

Soon will be listed here.

Abstract

Pain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is believed that RA-associated pain is not solely due to inflammation, but could also be attributed to aberrant modifications to the central nervous system. The P2X4 receptor (P2X4R) is an ATP-activated purinergic receptor that plays a significant role in the transmission of information in the nervous system and pain. The involvement of P2X4R during the pathogenesis of chronic inflammatory pain and neuropathic pain is well-established. The attenuation of this receptor alleviates disease pathogenesis and related symptoms, including hyperalgesia and allodynia. Although some studies have revealed the contribution of P2X4R in promoting joint inflammation in RA, how it implicates pain associated with RA at peripheral and central nervous systems is still lacking. In this review, the possible contributions of P2X4R in the nervous system and how it implicates pain transmission and responses were examined.

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