The Goto-Kakizaki Rat is a Spontaneous Prototypical Rodent Model of Polycystic Ovary Syndrome

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Feb 17

PMID 33594056

Citations 12

Authors

Camille Bourgneuf

Danielle Bailbe

Antonin Lamaziere

Charlotte Dupont

Marthe Moldes

Dominique Farabos

Natacha Roblot

Camille Gauthier

Emmanuelle Mathieu dArgent

Joelle Cohen-Tannoudji

Danielle Monniaux

Bruno Feve

Jamileh Movassat

Nathalie di Clemente

Chrystele Racine

Affiliations

Soon will be listed here.

Abstract

Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all the reproductive and metabolic hallmarks of lean women with PCOS at puberty and in adulthood. The analysis of their gestation and of their fetuses demonstrates that this PCOS-like phenotype is developmentally programmed. GK rats also develop features of ovarian hyperstimulation syndrome. Lastly, a comparison between GK rats and a cohort of women with PCOS reveals a similar reproductive signature. Thus, this spontaneous rodent model of PCOS represents an original tool for the identification of the mechanisms involved in its pathogenesis and for the development of novel strategies for its treatment.

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