Emotional Arousal Impairs Association Memory: Roles of Prefrontal Cortex Regions

Overview

Journal Learn Mem

Specialty Neurology

Date 2021 Feb 17

PMID 33593925

Citations 1

Authors

Esther Fujiwara

Christopher R Madan

Jeremy B Caplan

Tobias Sommer

Affiliations

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Abstract

The brain processes underlying impairing effects of emotional arousal on associative memory were previously attributed to two dissociable routes using high-resolution fMRI of the MTL (Madan et al. 2017). Extrahippocampal MTL regions supporting associative encoding of neutral pairs suggested unitization; conversely, associative encoding of negative pairs involved compensatory hippocampal activity. Here, whole-brain fMRI revealed prefrontal contributions: dmPFC was more involved in hippocampal-dependent negative pair learning and vmPFC in extrahippocampal neutral pair learning. Successful encoding of emotional memory associations may require emotion regulation/conflict resolution (dmPFC), while neutral memory associations may be accomplished by anchoring new information to prior knowledge (vmPFC).

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