Impact of Bariatric Surgery on Sexual Dysfunction in Obese Men

Overview

Journal Sex Med

Publisher Oxford University Press

Date 2021 Feb 16

PMID 33592350

Citations 8

Authors

Ahmed Fahmy

Hussien Abdeldaiem

Mohamed Abdelsattar

Tamer Aboyoussif

Akram Assem

Abdelrahman Zahran

Omar Elgebaly

Affiliations

Soon will be listed here.

Abstract

Introduction: Currently bariatric surgery is the most effective treatment for significant and sustained weight loss. Erectile and endothelial dysfunctions may share some metabolic and vascular pathways in common that may be influenced by weight loss.

Aim: The aim of the study was to assess the impact of surgically induced weight loss on the erectile function on obese patients undergoing laparoscopic sleeve gastrectomy (LSG). We also aimed to examine the proposed underlying mechanism associated with improvement in erectile function after weight loss by LSG.

Methods: Eighty-two consecutive obese men who underwent a LGS were followed up for 12 months. All operations were performed by the same surgeon at a single institution.

Main Outcome Measure: Patients were examined both before and after 12 months of LSG for biochemical tests; total serum cholesterol, triglyceride, C-reactive protein, interleukin-6, and endothelial nitric oxide synthase, and for erectile function tests. International Index of Erectile Function (IIEF) scores were recorded.

Results: Eighty-two men (mean age 39 ± 14.6 years, range 24-62; mean BMI 41.2 ± 4.8 kg/m) completed all preoperative and postoperative questionnaires and biochemical tests. At 12 months, the mean weight loss was 34.8 kg and the mean BMI decrease was 8.6 kg/m. Preoperative and postoperative IIEF scores of the 65 sexually active patients showed significant improvement in erectile function (21.2 ± 5.7 vs 26.5 ± 4.5; P = .02). Seventeen (20.7%) men were not sexually active preoperatively; only 5 became sexually active postoperatively. Men had a significant decrease in serum cholesterol and triglyceride levels. Nitric oxide synthase activity showed a significant increase (P < .02). In addition, our patients showed a statistically significant decrease in interleukin-6 levels and C-reactive protein compared with preoperative period (P < .03 and P < .01, respectively).

Conclusion: A significant improvement of erectile function was documented among obese young men undergoing LGS. This improvement was documented both clinically by improvement in IIEF score postoperatively and biochemically. A Fahmy, H Abdeldaiem, M Abdelsattar, et al. Impact of Bariatric Surgery on Sexual Dysfunction in Obese Men. Sex Med 2021;9:100322.

Citing Articles

Erectile Dysfunction Therapy of Bariatric Patients: Tadalafil Biopharmaceutics and Pharmacokinetics Before vs. After Gastric Sleeve/Bypass.

Porat D, Dukhno O, Cvijic S, Dahan A AAPS J. 2024; 26(6):114.

PMID: 39543061 DOI: 10.1208/s12248-024-00985-9.

Study on serum metabolomics characteristics of obese patients with erectile dysfunction.

Lin Y, Pan R, Deng R, Fang S, Yang H, Zhang X Medicine (Baltimore). 2024; 103(43):e40093.

PMID: 39470567 PMC: 11521011. DOI: 10.1097/MD.0000000000040093.

Sexual and Urinary Health among Women following Bariatric Surgery.

Lopez A, Carter J, Rubin R, Allen I, Shaw N, Hampson L Obes Surg. 2024; 34(11):4146-4151.

PMID: 39160367 PMC: 11541256. DOI: 10.1007/s11695-024-07226-0.

ROUX-en-Y gastric bypass surgery improves metabolic syndrome-related erectile dysfunction in mice via the IRS-1/PI3K/AKT/eNOS pathway.

Hu Z, Chen K, Dai H, Lv Z, Li J, Yu P Sex Med. 2024; 12(2):qfae029.

PMID: 38817951 PMC: 11134102. DOI: 10.1093/sexmed/qfae029.

The Complexity of Bariatric Patient's Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass.

Porat D, Dukhno O, Cvijic S, Dahan A Pharmaceutics. 2023; 15(12).

PMID: 38140135 PMC: 10747454. DOI: 10.3390/pharmaceutics15122795.

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