Remdesivir-Associated Pancreatitis

Overview

Journal Am J Ther

Specialty Pharmacology

Date 2021 Feb 16

PMID 33590992

Citations 7

Authors

Sushmita Khadka

Karen Williams

Shantanu Solanki

Affiliations

Soon will be listed here.

Abstract

We report a case of acute pancreatitis that developed after four days of remdesivir therapy in a patient being treated for COVID-19. Despite improvement in patient's respiratory status, abdominal pain worsened and clinical signs and symptoms progressed to a diagnosis of acute pancreatitis 4 days after initiation of remdesivir therapy. Withdrawal of remdesivir paired with medical management of acute pancreatitis led to the resolution of pancreatitis within three days. To our knowledge, this is the first case report depicting remdesivir as a possible cause of acute pancreatitis.

Citing Articles

Risk factors for drug-related acute pancreatitis: an analysis of the FDA adverse event reporting system (FAERS).

Zhang L, Mao W, Liu D, Hu B, Lin X, Ran J Front Pharmacol. 2023; 14:1231320.

PMID: 38044938 PMC: 10690789. DOI: 10.3389/fphar.2023.1231320.

Role of the SARS‑COV2 infection in the evolution of acute pancreatitis (Review).

Padureanu V, Caragea D, Florescu M, Vladu I, Radulescu P, Florescu D Biomed Rep. 2023; 19(1):49.

PMID: 37383680 PMC: 10293881. DOI: 10.3892/br.2023.1632.

Occam's razor or Hickam's dictum-COVID-19 is not a textbook aetiology of acute pancreatitis: A modified Naranjo Score appraisal.

Teng T, Chua B, Lim P, Chan K, Shelat V World J Gastroenterol. 2023; 29(13):2050-2063.

PMID: 37155526 PMC: 10122789. DOI: 10.3748/wjg.v29.i13.2050.

The burden of acute pancreatitis on COVID-19 in the United States.

Chaudhry H, Sohal A, Kohli I, Dukovic D, Sharma R, Singla P Ann Gastroenterol. 2023; 36(2):208-215.

PMID: 36864935 PMC: 9932859. DOI: 10.20524/aog.2023.0782.

The Pancreas in Coronavirus Disease 2019 Infection.

Correia de Sa T, Rocha M Gastroenterol Clin North Am. 2023; 52(1):37-48.

PMID: 36813429 PMC: 9744682. DOI: 10.1016/j.gtc.2022.12.002.