Diabetes, Gender and Deterioration in Estimated Glomerular Filtration Rate in Patients with Chronic Heart Failure: Ten-year Prospective Cohort Study

Overview

Journal Diab Vasc Dis Res

Publisher Sage Publications

Specialty Cardiology & Vascular Diseases

Date 2021 Feb 16

PMID 33588611

Citations 1

Authors

Jessica Kearney

Michael Drozd

Andrew Mn Walker

Thomas A Slater

Sam Straw

John Gierula

Maria Paton

Judith Lowry

Charlotte Cole

Klaus K Witte

Richard M Cubbon

Mark T Kearney

Affiliations

Soon will be listed here.

Abstract

Introduction: We aimed to evaluate the relationship between temporal changes in renal function and long-term mortality in patients with heart failure with reduced ejection fraction (HFrEF) and identify correlates of deteriorating renal function.

Methods: A total of 381 patients with HFrEF enrolled in a prospective cohort study between 2006-2014 had eGFR measured at initial visit and at 1 year. Baseline characteristics were used in a multivariate analysis to establish variables that predict deterioration in eGFR. Follow-up data were used to assess whether declining eGFR was related to outcomes.

Results: Patients were grouped into tertiles based on percentage change in eGFR. In a multivariate logistic regression analysis, male sex was associated with a 1.77-fold ([95% CI 1.01-2.89]; = 0.045) and diabetes a 1.66-fold ([95% CI 1.02-2.70]; = 0.041) greater risk of a decline in eGFR compared to those with stable/improving eGFR. Declining eGFR was associated with a 1.4-fold greater risk of death over 10 years ([95% CI 1.08-1.86]; = 0.01) and a 3.12-fold ([1.44-6.75]; = 0.004) greater risk of death at 1 year from second eGFR measurement.

Conclusions: In patients with HFrEF diabetes and male sex are independent predictors of a decline in eGFR at 1 year. A decline eGFR over 1 year is associated with higher long-term all-cause mortality.

Citing Articles

Association Between Diabetes, Chronic Kidney Disease, and Outcomes in People With Heart Failure From Asia.

Lawson C, Tay W, Bernhardt L, Richards A, Zaccardi F, Tromp J JACC Asia. 2023; 3(4):611-621.

PMID: 37614542 PMC: 10442874. DOI: 10.1016/j.jacasi.2023.03.005.

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