Nerve Growth Factor (NGF) and NGF Receptors in Mesenchymal Stem/stromal Cells: Impact on Potential Therapies

Overview

Journal Stem Cells Transl Med

Publisher Oxford University Press

Specialties Cell Biology
Pharmacology

Date 2021 Feb 15

PMID 33586908

Citations 29

Authors

Kangkang Zha

Yu Yang

Guangzhao Tian

Zhiqiang Sun

Zhen Yang

Xu Li

Xiang Sui

Shuyun Liu

Jinmin Zhao

Quanyi Guo

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate the biological behaviors of MSCs. The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis. The regulatory effect of NGF on MSCs is thought to be achieved mainly through its binding to TrkA. p75NTR, another receptor of NGF, is regarded as a novel surface marker of MSCs. This review provides an overview of advances in understanding the roles of NGF and its receptors in MSCs as well as the effects of MSC-derived NGF on other cell types, which will provide new insight for the optimization of MSC-based therapy.

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