Hypoxia in Cell Reprogramming and the Epigenetic Regulations

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Feb 15

PMID 33585477

Citations 13

Authors

Nariaki Nakamura

Xiaobing Shi

Radbod Darabi

Yong Li

Affiliations

Soon will be listed here.

Abstract

Cellular reprogramming is a fundamental topic in the research of stem cells and molecular biology. It is widely investigated and its understanding is crucial for learning about different aspects of development such as cell proliferation, determination of cell fate and stem cell renewal. Other factors involved during development include hypoxia and epigenetics, which play major roles in the development of tissues and organs. This review will discuss the involvement of hypoxia and epigenetics in the regulation of cellular reprogramming and how interplay between each factor can contribute to different cellular functions as well as tissue regeneration.

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References

Huels D, Medema J . Think About the Environment: Cellular Reprogramming by the Extracellular Matrix. Cell Stem Cell. 2018; 22(1):7-9. DOI: 10.1016/j.stem.2017.12.006. View

Koklanaris N, Nwachukwu J, Huang S, Guller S, Karpisheva K, Garabedian M . First-trimester trophoblast cell model gene response to hypoxia. Am J Obstet Gynecol. 2006; 194(3):687-93. DOI: 10.1016/j.ajog.2006.01.067. View

Alderman S, Crossley 2nd D, Elsey R, Gillis T . Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics. Sci Rep. 2019; 9(1):8592. PMC: 6565670. DOI: 10.1038/s41598-019-45023-3. View

Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T . Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol. 2012; 32(15):3018-32. PMC: 3434521. DOI: 10.1128/MCB.06643-11. View

Juan A, Derfoul A, Feng X, Ryall J, DellOrso S, Pasut A . Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells. Genes Dev. 2011; 25(8):789-94. PMC: 3078704. DOI: 10.1101/gad.2027911. View

Pan G, Thomson J . Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 2007; 17(1):42-9. DOI: 10.1038/sj.cr.7310125. View

Vojnits K, Pan H, Dai X, Sun H, Tong Q, Darabi R . Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications. Sci Rep. 2017; 7(1):1177. PMC: 5430871. DOI: 10.1038/s41598-017-01311-4. View

Larue L, Bellacosa A . Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene. 2005; 24(50):7443-54. DOI: 10.1038/sj.onc.1209091. View

Harrison C . Structure-based drug design: Opening the door to an epigenetic target. Nat Rev Drug Discov. 2012; 11(9):672. DOI: 10.1038/nrd3827. View

10.

Tsuji K, Kitamura S, Makino H . Hypoxia-inducible factor 1α regulates branching morphogenesis during kidney development. Biochem Biophys Res Commun. 2014; 447(1):108-14. DOI: 10.1016/j.bbrc.2014.03.111. View

11.

Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L . UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J Clin Invest. 2016; 126(4):1555-65. PMC: 4811158. DOI: 10.1172/JCI83239. View

12.

Vojnits K, Pan H, Mu X, Li Y . Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells. Sci Rep. 2015; 5:17355. PMC: 4661568. DOI: 10.1038/srep17355. View

13.

Shyh-Chang N, Zhu H, de Soysa T, Shinoda G, Seligson M, Tsanov K . Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013; 155(4):778-92. PMC: 3917449. DOI: 10.1016/j.cell.2013.09.059. View

14.

Covello K, Kehler J, Yu H, Gordan J, Arsham A, Hu C . HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006; 20(5):557-70. PMC: 1410808. DOI: 10.1101/gad.1399906. View

15.

Yang X, Yang S, Wang C, Kuang S . The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration. J Biol Chem. 2017; 292(14):5981-5991. PMC: 5392588. DOI: 10.1074/jbc.M116.756312. View

16.

Han S, Han S, Coh Y, Jang G, Ra J, Kang S . Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells. Exp Mol Med. 2014; 46:e101. PMC: 4081551. DOI: 10.1038/emm.2014.28. View

17.

Zhang Z, Zhang L, Zhou Y, Li L, Zhao J, Qin W . Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia. Cell Death Dis. 2019; 10(8):552. PMC: 6639330. DOI: 10.1038/s41419-019-1763-2. View

18.

Koppens M, Bounova G, Gargiulo G, Tanger E, Janssen H, Cornelissen-Steijger P . Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells. Gastroenterology. 2016; 151(4):684-697.e12. DOI: 10.1053/j.gastro.2016.06.020. View

19.

Handy D, Castro R, Loscalzo J . Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011; 123(19):2145-56. PMC: 3107542. DOI: 10.1161/CIRCULATIONAHA.110.956839. View

20.

Wang S, Sun Y, Ren R, Xie J, Tian X, Zhao S . H3K27me3 Depletion during Differentiation Promotes Myogenic Transcription in Porcine Satellite Cells. Genes (Basel). 2019; 10(3). PMC: 6471710. DOI: 10.3390/genes10030231. View