: Host-Parasite Interactions and Pathogenesis

Overview

Journal Curr Clin Microbiol Rep

Specialty Microbiology

Date 2021 Feb 15

PMID 33585166

Citations 22

Authors

Derek J Pinto

Sumiti Vinayak

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: spp. ( and ) are a major cause of diarrhea-associated morbidity and mortality in young children globally. While only infects humans, is a zoonotic parasite that can be transmitted from infected animals to humans. There are no treatment or control measures to fully treat cryptosporidiosis or prevent the infection in humans and animals. Our knowledge on the molecular mechanisms of -host interactions and the underlying factors that govern infectivity and disease pathogenesis is very limited.

Recent Findings: Recent development of genetics and new animal models of infection, along with progress in cell culture platforms to complete the parasite lifecycle in vitro, is greatly advancing the field.

Summary: In this review, we will discuss our current knowledge of host-parasite interactions and how genetic manipulation of and promising infection models are opening the doors towards an improved understanding of parasite biology and disease pathogenesis.

Citing Articles

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A key regulator of male gametogenesis in Cryptosporidium.

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Human dendritic cell interactions with the zoonotic parasite result in activation and maturation.

Ross R, Hasheminasab S, Conejeros I, Gartner U, Kamena F, Krueger A Front Immunol. 2024; 15:1388366.

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TKL family kinases in human apicomplexan pathogens.

Ali D, Gaji R Mol Biochem Parasitol. 2024; 259:111628.

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Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in and HCT-8 Host Cells.

Ajiboye J, Uldry A, Heller M, Naguleswaran A, Fan E, Van Voorhis W Int J Mol Sci. 2024; 25(5).

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