» Articles » PMID: 33584878

Dielectrical Properties of Living Epidermis and Dermis in the Frequency Range from 1 KHz to 1 MHz

Overview
Specialty Biophysics
Date 2021 Feb 15
PMID 33584878
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

We determine the in-vivo dielectric properties-resistivity and relative permittivity-of living epidermis and dermis of human skin soaked with a physiological saline solution for one minute between 1 kHz and 1 MHz. This is done by fitting approximate analytical solutions of a mechanistic model for the transport of charges in these layers to a training set comprising impedance measurements at two depth settings on stripped skin on the volar forearm of 24 young subjects. Here, the depth settings are obtained by varying the voltage at a second inject on the electrical-impedance-spectroscopy probe. The model and the dielectric properties are validated with a test set for a third depth setting with overall good agreement. In addition, the means and standard deviations of the thicknesses of living epidermis and dermis are estimated from a literature review as 61±7 μm and 1.0±0.2 mm respectively. Furthermore, extensions to resolve the skin layers in more detail are suggested.

Citing Articles

A battery-less implantable glucose sensor based on electrical impedance spectroscopy.

Ollmar S, Fernandez Schrunder A, Birgersson U, Kristoffersson T, Rusu A, Thorsson E Sci Rep. 2023; 13(1):18122.

PMID: 37872272 PMC: 10593792. DOI: 10.1038/s41598-023-45154-8.


Skin layer classification by feedforward neural network in bioelectrical impedance spectroscopy.

Ibrahim K, Baidillah M, Wicaksono R, Takei M J Electr Bioimpedance. 2023; 14(1):19-31.

PMID: 37564279 PMC: 10411641. DOI: 10.2478/joeb-2023-0004.


Needle-Based Electrical Impedance Imaging Technology for Needle Navigation.

Liu J, Atmaca O, Pott P Bioengineering (Basel). 2023; 10(5).

PMID: 37237660 PMC: 10215279. DOI: 10.3390/bioengineering10050590.


Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.

Malysko-Ptasinske V, Staigvila G, Novickij V Front Bioeng Biotechnol. 2023; 10:1094968.

PMID: 36727038 PMC: 9885012. DOI: 10.3389/fbioe.2022.1094968.


Diabetic Foot Assessment using Skin Impedance in a Custom Made Sensor-sock.

Tronstad C, Amini M, Olesen E, Qvigstad E, Pabst O, Martinsen T J Electr Bioimpedance. 2023; 13(1):136-142.

PMID: 36694878 PMC: 9837869. DOI: 10.2478/joeb-2022-0019.


References
1.
Schwan H . Electrical properties of tissue and cell suspensions. Adv Biol Med Phys. 1957; 5:147-209. DOI: 10.1016/b978-1-4832-3111-2.50008-0. View

2.
Huzaira M, Rius F, Rajadhyaksha M, Anderson R, Gonzalez S . Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. J Invest Dermatol. 2001; 116(6):846-52. DOI: 10.1046/j.0022-202x.2001.01337.x. View

3.
Holbrook K, ODLAND G . Regional differences in the thickness (cell layers) of the human stratum corneum: an ultrastructural analysis. J Invest Dermatol. 1974; 62(4):415-22. DOI: 10.1111/1523-1747.ep12701670. View

4.
Egawa M, Hirao T, Takahashi M . In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Derm Venereol. 2007; 87(1):4-8. DOI: 10.2340/00015555-0183. View

5.
Neerken S, Lucassen G, Bisschop M, Lenderink E, Nuijs T . Characterization of age-related effects in human skin: A comparative study that applies confocal laser scanning microscopy and optical coherence tomography. J Biomed Opt. 2004; 9(2):274-81. DOI: 10.1117/1.1645795. View