A New Heterotropic Vascularized Model of Total Urinary Bladder Transplantation in a Rat Model

Overview

Journal Sci Rep

Specialty Science

Date 2021 Feb 13

PMID 33580157

Citations 1

Authors

Arkadiusz Jundzill

Henryk Witmanowski

Ewa Zary-Sikorska

Jan Adamowicz

Magdalena Bodnar

Andrzej Marszalek

Tomasz Kloskowski

Kaja Mecinska-Jundzill

Maciej Gagat

Natalia Siedlecka

Tomasz Drewa

Marta Pokrywczynska

Affiliations

Soon will be listed here.

Abstract

This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injection were performed to evaluate the proposed method's functionality. Observation time was four weeks. One week after the procedure, the graft survival rate was 80%, two urinary bladders were lost due to anastomosis failure. The rest of the grafts survived two weeks without any complications. Lack of transitional epithelium or smooth muscle layer loss and lack of inflammatory process development were observed. This study was performed in order to obtain the necessary knowledge about urinary bladder transplantation. The proposed technique offers a new approach to the existing orthotropic models.

Citing Articles

Urinary bladder transplantation in humans - current status and future perspectives.

Czarnogorski M, Koper K, Petrasz P, Vetterlein M, Pokrywczynska M, Juszczak K Nat Rev Urol. 2024; 22(3):175-186.

PMID: 39304780 DOI: 10.1038/s41585-024-00935-2.

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