A Simple Cerium Coating Strategy for Titanium Oxide Nano-tubes' Bioactivity Enhancement

Overview

Journal Nanomaterials (Basel)

Date 2021 Feb 13

PMID 33578788

Citations 7

Authors

Serena De Santis

Giovanni Sotgiu

Francesco Porcelli

Martina Marsotto

Giovanna Iucci

Monica Orsini

Affiliations

Soon will be listed here.

Abstract

Despite the well-known favorable chemical and mechanical properties of titanium-based materials for orthopedic and dental applications, poor osseointegration of the implants, bacteria adhesion, and excessive inflammatory response from the host remain major problems to be solved. Here, the antioxidant and anti-inflammatory enzyme-like abilities of ceria (CeO) were coupled to the advantageous features of titanium nanotubes (TiNTs). Cost-effective and fast methods, such as electrochemical anodization and drop casting, were used to build active surfaces with enhanced bioactivity. Surface composition, electrochemical response, and in vitro ability to induce hydroxyapatite (HA) precipitation were evaluated. The amount of cerium in the coating did not significantly affect wettability, yet a growing ability to induce early HA precipitation from simulated body fluid (SBF) was observed as the oxide content at the surface increased. The presence of 4%wt CeO was also able to stimulate rapid HA maturation in a (poorly) crystalline form, indicating an interesting potential to induce rapid in vivo osseointegration process.

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