» Articles » PMID: 33576776

Protection and Risk: Male and Female Genital Microbiota and Sexually Transmitted Infections

Overview
Journal J Infect Dis
Date 2021 Feb 12
PMID 33576776
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

Unique compositional and functional features of the cervicovaginal microbiota have been associated with protection against and risk for sexually transmitted infections (STI). In men, our knowledge of the interaction between the penile microbiota and STI is less developed. The current state of our understanding of these microbiota and their role in select STIs is briefly reviewed, along with strategies that leverage existing findings to manipulate genital microbiota and optimize protection against STIs. Finally, we focus on major research gaps and present a framework for future studies.

Citing Articles

Microbes Saving Lives and Reducing Suffering.

Timmis K, Karahan Z, Ramos J, Koren O, Perez-Cobas A, Steward K Microb Biotechnol. 2025; 18(1):e70068.

PMID: 39844583 PMC: 11754571. DOI: 10.1111/1751-7915.70068.


Water source, latrine type, and rainfall are associated with detection of non-optimal and enteric bacteria in the vaginal microbiome: a prospective observational cohort study nested within a cluster randomized controlled trial.

Czapar A, Paul S, Zulaika G, Otieno F, Agingu W, Chaudhary A BMC Infect Dis. 2024; 24(1):1419.

PMID: 39695422 PMC: 11653966. DOI: 10.1186/s12879-024-10313-3.


Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections.

Avitabile E, Menotti L, Croatti V, Giordani B, Parolin C, Vitali B Int J Mol Sci. 2024; 25(17).

PMID: 39273118 PMC: 11395631. DOI: 10.3390/ijms25179168.


Comparison of the urinary microbiome in men who have sex with men with and without Chlamydia trachomatis infection.

Mofolorunsho K, Mabaso N, Nundlall N, Ojo A, Cason E, Abbai N Eur J Clin Microbiol Infect Dis. 2024; 43(11):2159-2170.

PMID: 39259456 PMC: 11534976. DOI: 10.1007/s10096-024-04930-8.


Penile microbiome: decoding its impact on HIV risk.

Nelson S, Liu C Curr Opin HIV AIDS. 2024; 19(5):241-245.

PMID: 38935058 PMC: 11305963. DOI: 10.1097/COH.0000000000000865.


References
1.
Brotman R, Shardell M, Gajer P, Tracy J, Zenilman J, Ravel J . Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection. J Infect Dis. 2014; 210(11):1723-33. PMC: 4296189. DOI: 10.1093/infdis/jiu330. View

2.
Boskey E, Cone R, Whaley K, Moench T . Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum Reprod. 2001; 16(9):1809-13. DOI: 10.1093/humrep/16.9.1809. View

3.
Schwebke J, Lee J, Lensing S, Philip S, Wiesenfeld H, Sena A . Home Screening for Bacterial Vaginosis to Prevent Sexually Transmitted Diseases. Clin Infect Dis. 2015; 62(5):531-6. PMC: 4741364. DOI: 10.1093/cid/civ975. View

4.
Balkus J, Manhart L, Lee J, Anzala O, Kimani J, Schwebke J . Periodic Presumptive Treatment for Vaginal Infections May Reduce the Incidence of Sexually Transmitted Bacterial Infections. J Infect Dis. 2016; 213(12):1932-7. PMC: 4878720. DOI: 10.1093/infdis/jiw043. View

5.
Brookheart R, Lewis W, Peipert J, Lewis A, Allsworth J . Association between obesity and bacterial vaginosis as assessed by Nugent score. Am J Obstet Gynecol. 2019; 220(5):476.e1-476.e11. PMC: 7232937. DOI: 10.1016/j.ajog.2019.01.229. View