Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses Against in Rabbits

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2021 Feb 12

PMID 33575363

Citations 4

Authors

Xiao Chenwen

Ji Quanan

Huang Yee

Liu Yan

Wang Jiaoyu

Wei Qiang

Qiao Litao

Nan Li

Bao Guolian

Affiliations

Soon will be listed here.

Abstract

(. ) is an obligately aerobic, oxidase- and catalase-positive, nonfermentative Gram-negative coccobacillus. This study is aimed at examining the immune effects of Rg1, Rg1 plus oil, and other common adjuvants on inactivated . vaccine in rabbits. The mechanism underlying the adjuvant effect of Rg1 plus oil on the vaccine was also explored. Rg1 (100 g) plus oil significantly improved the immune effect of . vaccine at both the humoral and cellular levels. Rg1-oil adjuvant increased the levels of IL-2 and IL-4 in rabbits after immunization. Rg1 (100 g) plus oil also significantly increased TLR2 expression and downregulated NF-B in splenocytes. Rg1-oil adjuvant may increase the levels of IL-2 and IL-4 via upregulating TLR2, thereby enhancing the immune effect of . vaccine. In conclusion, Rg1 plus oil could be used as a potential vaccine adjuvant for rabbit . vaccine.

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