Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming Through Modulating STAT3 and Erk1/2 Activity

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Feb 12

PMID 33572536

Citations 3

Authors

Yu-Hao Liu

Chien-Chang Chen

Yi-Jen Hsueh

Li-Man Hung

David Hui-Kang Ma

Hung-Chi Chen

Wen-Bin Len

Yaa-Jyuhn J Meir

Affiliations

Soon will be listed here.

Abstract

Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular events that participate in the selection of such processes at the onset of somatic reprogramming. The activity of STAT3 versus that of Erk1/2 reversibly determines the reprogramming mode entered; a lower activity ratio favors the deterministic process and vice versa. Additionally, extraneous E-cadherin facilitates the early events of somatic reprogramming, potentially by stabilizing the LIF/gp130 and EGFR/ErbB2 complexes to promote entry into the deterministic process. Our current findings demonstrated that manipulating the pSTAT3/pErk1/2 activity ratio in the surrounding milieu can drive different modes of action toward either the deterministic or the stochastic process in the context of OSKM-mediated somatic reprogramming.

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