New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Y32-2

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Feb 12

PMID 33572212

Citations 11

Authors

Peihai Li

Mengqi Zhang

Haonan Li

Rongchun Wang

Hairong Hou

Xiaobin Li

Kechun Liu

Hao Chen

Affiliations

Soon will be listed here.

Abstract

Chemical investigation of secondary metabolites from the marine-derived fungus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E () and dinotoamide J (), one new pteridine alkaloid asperpteridinate A (), with eleven known compounds (-). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds , , , , exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds , , , displayed anti-inflammatory activity in a CuSO-induced zebrafish inflammation model, and compound showed significant cytotoxicity against HepG2 cells with an IC value of 30 µg/mL.

Citing Articles

Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules.

Liu C, Li J, Wang D, Liu J, Liu K, Li P Mar Drugs. 2024; 22(12).

PMID: 39728115 PMC: 11678508. DOI: 10.3390/md22120540.

Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity.

Qiu Y, Chen S, Yu M, Shi J, Liu J, Li X Mar Drugs. 2024; 22(10).

PMID: 39452841 PMC: 11509926. DOI: 10.3390/md22100433.

Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms.

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Recent Discovery of Nitrogen Heterocycles from Marine-Derived Species.

Shi J, Yu M, Chen W, Chen S, Qiu Y, Xu Z Mar Drugs. 2024; 22(7).

PMID: 39057430 PMC: 11277891. DOI: 10.3390/md22070321.

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications.

Fernandez S, Arnaiz V, Rufo D, Arroyo Y Mar Drugs. 2024; 22(3).

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