» Articles » PMID: 33572212

New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Y32-2

Overview
Journal Mar Drugs
Publisher MDPI
Specialties Biology
Pharmacology
Date 2021 Feb 12
PMID 33572212
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

Chemical investigation of secondary metabolites from the marine-derived fungus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E () and dinotoamide J (), one new pteridine alkaloid asperpteridinate A (), with eleven known compounds (-). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds , , , , exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds , , , displayed anti-inflammatory activity in a CuSO-induced zebrafish inflammation model, and compound showed significant cytotoxicity against HepG2 cells with an IC value of 30 µg/mL.

Citing Articles

Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules.

Liu C, Li J, Wang D, Liu J, Liu K, Li P Mar Drugs. 2024; 22(12).

PMID: 39728115 PMC: 11678508. DOI: 10.3390/md22120540.


Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity.

Qiu Y, Chen S, Yu M, Shi J, Liu J, Li X Mar Drugs. 2024; 22(10).

PMID: 39452841 PMC: 11509926. DOI: 10.3390/md22100433.


Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms.

Yang G, Lin M, Kaliaperumal K, Lu Y, Qi X, Jiang X Mar Drugs. 2024; 22(9).

PMID: 39330305 PMC: 11433063. DOI: 10.3390/md22090424.


Recent Discovery of Nitrogen Heterocycles from Marine-Derived Species.

Shi J, Yu M, Chen W, Chen S, Qiu Y, Xu Z Mar Drugs. 2024; 22(7).

PMID: 39057430 PMC: 11277891. DOI: 10.3390/md22070321.


Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications.

Fernandez S, Arnaiz V, Rufo D, Arroyo Y Mar Drugs. 2024; 22(3).

PMID: 38535467 PMC: 10971852. DOI: 10.3390/md22030126.


References
1.
Ma H, Liu Q, Zhu G, Liu H, Zhu W . Marine natural products sourced from marine-derived Penicillium fungi. J Asian Nat Prod Res. 2016; 18(1):92-115. DOI: 10.1080/10286020.2015.1127230. View

2.
Parrino B, Carbone D, Cascioferro S, Pecoraro C, Giovannetti E, Deng D . 1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A. Eur J Med Chem. 2020; 209:112892. DOI: 10.1016/j.ejmech.2020.112892. View

3.
Stephens P, Harada N . ECD cotton effect approximated by the Gaussian curve and other methods. Chirality. 2009; 22(2):229-33. DOI: 10.1002/chir.20733. View

4.
Lee Y, Kim M, Li H, Zhang P, Bao B, Lee K . Marine-derived Aspergillus species as a source of bioactive secondary metabolites. Mar Biotechnol (NY). 2013; 15(5):499-519. DOI: 10.1007/s10126-013-9506-3. View

5.
Qi J, Liu S, Liu W, Cai G, Liao G . Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6. Aging (Albany NY). 2020; 12(8):6904-6927. PMC: 7202507. DOI: 10.18632/aging.103050. View