Metabolic Regulation of Tendon Inflammation and Healing Following Injury

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2021 Feb 11

PMID 33569739

Citations 17

Authors

Jessica E Ackerman

Katherine T Best

Samantha N Muscat

Alayna E Loiselle

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis.

Recent Findings: Recent advances in the field include a substantial improvement in our understanding of tendon cell biology, including the heterogeneity of the tenocyte environment during homeostasis, the diversity of the cellular milieu during in vivo tendon healing, and the effects of inflammation and altered metabolism on tendon cell function in vitro. In addition, the mechanisms by which altered systemic metabolism, such as diabetes, disrupts tendon homeostasis continue to be better understood. A central conclusion of this review is the critical need to better define fundamental cellular and signaling mechanisms of inflammation and metabolism during tendon homeostasis, tendinopathy, and tendon healing in order to identify therapies to enhance or maintain tendon function.

Citing Articles

AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon.

Hold L, Migotsky N, Lamia S, Steltzer S, Grossman S, Chen J bioRxiv. 2025; .

PMID: 39975248 PMC: 11838443. DOI: 10.1101/2025.01.31.635920.

Coordination of Glucose and Glutamine Metabolism in Tendon is Lost in Aging.

Mlawer S, Pinto F, Sikes K, Connizzo B bioRxiv. 2025; .

PMID: 39763790 PMC: 11702705. DOI: 10.1101/2024.12.19.629426.

Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon.

Tamburro M, Bonilla K, Shetye S, Leahy T, Eekhoff J, Kim M J Orthop Res. 2024; 43(3):519-530.

PMID: 39731286 PMC: 11806652. DOI: 10.1002/jor.26030.

Dendritic Cell-Derived Exosomes Promote Tendon Healing and Regulate Macrophage Polarization in Preventing Tendinopathy.

Chen R, Ai L, Zhang J, Jiang D Int J Nanomedicine. 2024; 19:11701-11718.

PMID: 39558915 PMC: 11571930. DOI: 10.2147/IJN.S466363.

Advanced glycation end products impair the repair of injured tendon: a study in rats.

Yang J, He J, Yang L BMC Musculoskelet Disord. 2024; 25(1):700.

PMID: 39227794 PMC: 11370031. DOI: 10.1186/s12891-024-07760-z.

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