Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2021 Feb 10

PMID 33567075

Citations 15

Authors

Cristiana Cipriani

Salvatore Minisola

John P Bilezikian

Davide Diacinti

Luciano Colangelo

Valentina Piazzolla

Maurizio Angelozzi

Luciano Nieddu

Jessica Pepe

Daniele Diacinti

Affiliations

Soon will be listed here.

Abstract

Context: Hypoparathyroidism is a rare endocrine disorder whose skeletal features include suppression of bone turnover and greater volume and width of the trabecular compartment. Few and inconsistent data are available on the prevalence of vertebral fractures (VF).

Objective: To evaluate the prevalence of VF assessed by vertebral fracture assessment (VFA) in postmenopausal women with chronic postsurgical hypoparathyroidism.

Design: Cross-sectional study.

Setting: Ambulatory referral center.

Patients Or Other Participants: Fifty postmenopausal women (mean age 65.4 ± 9 years) with chronic postsurgical hypoparathyroidism and 40 age-matched healthy postmenopausal women (mean age 64.2 ± 8.6).

Main Outcome Measures: Lumbar spine, femoral neck, and total hip bone mineral density were measured by dual X-ray absorptiometry (Hologic Inc., USA) in all subjects. Site-matched spine trabecular bone score was calculated by TBS iNsight (Medimaps, Switzerland). Assessment of VF was made by VFA (iDXA, Lunar GE, USA) using the semiquantitative method and the algorithm-based qualitative assessment.

Results: All-site BMD values were higher in the hypoparathyroid vs the control group. By VFA, we observed a 16% prevalence of VF in hypoparathyroid women vs 7.5% in control subjects. Among those with hypoparathyroidism who fractured, 5 (62.5%) had grade 1 wedge, 2 (25%) had grade 2 wedge, and 1 (12.5%) had grade 2 wedge and grade 2 biconcave VF. In the hypoparathyroid group, 57% with VFs and 32% without VFs had symptoms of hypoparathyroidism.

Conclusion: We demonstrate for the first time that in postmenopausal women with chronic postsurgical hypoparathyroidism, VFs are demonstrable by VFA despite normal BMD.

Citing Articles

Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR).

Khan A, AbuAlrob H, Ali D, Al Kassem Z, Almoulia A, Afifi H Osteoporos Int. 2025; .

PMID: 39955688 DOI: 10.1007/s00198-025-07410-7.

Hypoparathyroidism: diagnosis, management and emerging therapies.

Khan S, Khan A Nat Rev Endocrinol. 2025; .

PMID: 39905273 DOI: 10.1038/s41574-024-01075-8.

Prevalence of chronic postsurgical hypoparathyroidism not adequately controlled: an analysis of a nationwide cohort of 337 patients.

Diez J, Anda E, Perez-Corral B, Paja M, Alcazar V, Sanchez-Ragnarsson C Front Endocrinol (Lausanne). 2024; 15:1464515.

PMID: 39387052 PMC: 11461294. DOI: 10.3389/fendo.2024.1464515.

Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.

Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, Nieddu L Nutrients. 2024; 16(11).

PMID: 38892687 PMC: 11174435. DOI: 10.3390/nu16111754.

Preclinical development of EXT608, an investigational parathyroid hormone derivative with extended half-life for the treatment of hypoparathyroidism.

Hall D, Kostyla C, Hales L, Soliman T JBMR Plus. 2024; 8(6):ziae045.

PMID: 38721043 PMC: 11078046. DOI: 10.1093/jbmrpl/ziae045.

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