Efficacy of Autologous Platelet-rich Plasma Gel in the Treatment of Refractory Pressure Injuries and Its Effect on Wound Healing Time and Patient Quality of Life

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2021 Feb 10

PMID 33567047

Citations 11

Authors

Qian Liu

Ning Zhang

Zhengnan Li

Hongmei He

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.

Methods: A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel.

Results: The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05).

Conclusion: In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.

Citing Articles

The Efficacy and Safety of Negative-Pressure Wound Therapy Combined With Platelet-Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Hao R, Luo M, Xiao Y, Li J, Lv X, Peng Y Health Sci Rep. 2024; 7(11):e70205.

PMID: 39587994 PMC: 11586636. DOI: 10.1002/hsr2.70205.

The application effect of autologous platelet-rich plasma combined with negative pressure sealing drainage technology in pressure ulcer wound repair.

Tian B, Yang X, Liu Y, Wei C, Liu D, Ren X Medicine (Baltimore). 2024; 103(44):e39672.

PMID: 39496059 PMC: 11537577. DOI: 10.1097/MD.0000000000039672.

Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care.

Perussolo J, Calciolari E, Dereka X, Donos N Periodontol 2000. 2024; 97(1):320-341.

PMID: 39056422 PMC: 11808476. DOI: 10.1111/prd.12572.

Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies.

Mehdipour Chari K, Enderami S, Mansour R, Hasanzadeh E, Mahabadi J, Abazari M Regen Ther. 2024; 27:251-258.

PMID: 38596823 PMC: 11002853. DOI: 10.1016/j.reth.2024.02.011.

Green Synthesis of Zinc Oxide Nanoparticles from Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways.

Elhabal S, Abdelaal N, Saeed Al-Zuhairy S, Elrefai M, Hamdan A, Khalifa M Int J Nanomedicine. 2024; 19:3045-3070.

PMID: 38559447 PMC: 10981898. DOI: 10.2147/IJN.S455270.

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