Alpha 2.0
Login Register
» Articles » PMID: 33566203

Long-term Serological Follow-up After Primary Coxiella Burnetii Infection in Patients with Vascular Risk Factors for Chronic Q Fever

Overview
Journal Eur J Clin Microbiol Infect Dis
Publisher Springer
Specialties Infectious Diseases
Microbiology
Date 2021 Feb 10
PMID 33566203
Citations 3
Authors
Sheila B Buijs
Sanne K Stuart
Jan Jelrik Oosterheert
Steffi Karhof
Andy I M Hoepelman
Nicole H M Renders
Andre S van Petersen
Chantal P Bleeker-Rovers
Peter C Wever
Olivier H J Koning
Affiliations
Soon will be listed here.
Abstract

We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.

Citing Articles

No Influence of Previous Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2.

Weehuizen J, van Spronsen R, Hoepelman A, Bleeker-Rovers C, Oosterheert J, Wever P J Clin Med. 2022; 11(3).

PMID: 35159977 PMC: 8836776. DOI: 10.3390/jcm11030526.

Molecular diagnosis of in culture negative endocarditis and vascular infection in South Korea.

Bae M, Lee H, Park J, Bae S, Jung J, Kim M Ann Med. 2021; 53(1):2256-2265.

PMID: 34809520 PMC: 8805875. DOI: 10.1080/07853890.2021.2005821.

Seroprevalence and risk factors of antibodies against among dog owners in southwestern Québec, Canada.

Duplaix L, Turgeon P, Levesque B, Rocheleau J, Leboeuf A, Picard I Epidemiol Infect. 2021; :1-45.

PMID: 34176524 PMC: 8314959. DOI: 10.1017/S0950268821001412.

References
1.
Kampschreur L, Dekker S, Hagenaars J, Lestrade P, Renders N, de Jager-Leclercq M . Identification of risk factors for chronic Q fever, the Netherlands. Emerg Infect Dis. 2012; 18(4):563-70. PMC: 3309671. DOI: 10.3201/eid1804.111478. View
2.
Hagenaars J, Renders N, van Petersen A, Shamelian S, de Jager-Leclercq M, Moll F . Serological follow-up in patients with aorto-iliac disease and evidence of Q fever infection. Eur J Clin Microbiol Infect Dis. 2014; 33(8):1407-14. DOI: 10.1007/s10096-014-2084-0. View
3.
Schneeberger P, Hermans M, van Hannen E, Schellekens J, Leenders A, Wever P . Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever. Clin Vaccine Immunol. 2009; 17(2):286-90. PMC: 2815520. DOI: 10.1128/CVI.00454-09. View
4.
de Lange M, Gijsen L, Wielders C, van der Hoek W, Scheepmaker A, Schneeberger P . Should Acute Q-Fever Patients be Screened for Valvulopathy to Prevent Endocarditis?. Clin Infect Dis. 2018; 67(3):360-366. PMC: 6051461. DOI: 10.1093/cid/ciy128. View
5.
Morroy G, van der Hoek W, Albers J, Coutinho R, Bleeker-Rovers C, Schneeberger P . Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. PLoS One. 2015; 10(7):e0131777. PMC: 4489093. DOI: 10.1371/journal.pone.0131777. View