Podocyte and Tubular Involvement in AngioJet-induced Kidney Injury
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The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
Al-Mannai N, Sibira D, Alsuwaidi H, Elmagdoub A, Habas E, Alfitori G Clin Case Rep. 2024; 12(10):e9263.
PMID: 39328294 PMC: 11423260. DOI: 10.1002/ccr3.9263.
Observation of the effect of angiojet to treat acute lower extremity arterial embolization.
Meng X, Xie X, Liu Y, Huang C, Wang L, Liu H World J Clin Cases. 2023; 11(15):3491-3501.
PMID: 37383913 PMC: 10294201. DOI: 10.12998/wjcc.v11.i15.3491.
Gong M, Fu G, Liu Z, Zhou Y, Zhao B, Kong J Digit Health. 2023; 9:20552076231154691.
PMID: 36776409 PMC: 9909069. DOI: 10.1177/20552076231154691.
Jiang G, Ding D, Zhang X, Niu S, Lyu B Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022; 51(3):341-349.
PMID: 36161716 PMC: 9511488. DOI: 10.3724/zdxbyxb-2022-0121.
Unclogging the effects of the Angiojet® thrombectomy system on kidney function: a case report.
Roper T, Amaran M, Saha P, Breen C, Game D J Med Case Rep. 2021; 15(1):459.
PMID: 34503554 PMC: 8431865. DOI: 10.1186/s13256-021-03062-3.