Obstructive Sleep Apnea, Intermittent Hypoxemia and Prothrombotic Biomarkers

Overview

Journal Sleep Sci

Publisher Thieme

Date 2021 Feb 10

PMID 33564369

Authors

Kunal Deokar

Sushant Meshram

Gopal Chawla

Nana Kunjir

Chetna Meshram

Nupur Abrol

Priyanka Gaikwad

Affiliations

Soon will be listed here.

Abstract

Objective: To study the serum levels of ﬁbrinogen and d-dimer in patients with obstructive sleep apnea (OSA) and its correlation with apnea hypopnea index (AHI), oxygen desaturation index (ODI), minimal oxygen saturation and arousal index.

Methods: It was a case control study in which 23 cases of OSA and 23 controls were enrolled. Morning fasting serum ﬁbrinogen and d-dimer were measured in cases of OSA and controls.

Results: Serum ﬁbrinogen levels among OSA patients (268.47±53.11mg/dl) were elevated as compared to the levels in controls (221.52±65.84mg/dl) (p<0.05). Serum ﬁbrinogen co-related positively with AHI (r=0.6381, p=0.0011) and ODI (r=0.7434, p=0.0000), negatively with minimal oxygen saturation (r=-0.4461, p=0.0329). There was no statistically signiﬁcant correlation of ﬁbrinogen with arousal index (r=0.2697, p=0.2133). There was no statistically signiﬁcant difference between mean fasting d-dimer level in cases (0.12mg/L, 0.06±0.18mg/L) and controls (0.12mg/L, 0.02±0.22mg/L) (p=0.8926).

Conclusions: The observation of elevated ﬁbrinogen levels with the increasing severity of OSA and hypoxemic events makes OSA one of the important risk factor for cardiovascular disorders.

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