The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer's Disease and Mild Cognitive Impairment

Overview

Journal Psychiatry Investig

Specialty Psychiatry

Date 2021 Feb 10

PMID 33561929

Citations 11

Authors

Jun Kyung Park

Kang Joon Lee

Ji Yeon Kim

Hyun Kim

Affiliations

Soon will be listed here.

Abstract

Objective: Many patients suffer from dementia in its most common form, Alzheimer's disease (AD). In this study, the levels of IL-1β, TGF-β and CRP, which are involved in the inflammatory response in Alzheimer's disease and its mild cognitive impairment (MCI), were measured and analyzed.

Methods: Seventy nine subjects participated in this study (mean age: 75.56 years, female: 54.3%, AD: 26, MCI: 28, normal: 25). The overall cognitive function of the subjects and the severity of the disease stage were assessed using the Mini-Mental State Examination (MMSE-K), the Clinical Dementia Rating (CDR), the Global Deterioration Scale (GDS) and the Geriatric Depression Scale-Korean (GDS-K).

Results: It was observed that patients with AD had significantly higher levels of IL-1β and TGF-β than the patients with MCI and normal controls. In addition, the MCI group showed a statistically significantly higher TGF-β concentration than the normal group.

Conclusion: These results suggest that IL-1β and TGF-β may be useful biological markers for patients with Alzheimer's disease.

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