Dissociating Disorders of Depression, Anxiety, and Their Comorbidity with Measures of Emotional Processing: A Joint Analysis of Visual Brain Potentials and Auditory Perceptual Asymmetries

Overview

Journal Biol Psychol

Specialty Psychiatry

Date 2021 Feb 8

PMID 33556452

Citations 1

Authors

Lidia Y X Panier

Priya Wickramaratne

Daniel M Alschuler

Myrna M Weissman

Jonathan E Posner

Marc J Gameroff

Gerard E Bruder

Jurgen Kayser

Affiliations

Soon will be listed here.

Abstract

In a multigenerational study of families at risk for depression, individuals with a lifetime history of depression had: 1) abnormal perceptual asymmetry (PA; smaller left ear/right hemisphere [RH] advantage) in a dichotic emotion recognition task, and 2) reduced RH late positive potential (P3) during an emotional hemifield task. We used standardized difference scores for processing auditory (PA sad-neutral) and visual (P3 negative-neutral) stimuli for 112 participants (52 men) in a logistic regression to predict history of depression, anxiety or comorbidity of both. Whereas comorbidity was separately predicted by reduced PA (OR = 0.527, p = .042) or P3 (OR = 0.457, p = .013) alone, an interaction between PA and P3 (OR = 2.499, p = .011) predicted depressive disorder. Follow-up analyses revealed increased probability of depression at low (lack of emotional differentiation) and high (heightened reactivity to negative stimuli) levels of both predictors. Findings suggest that reduced or heightened right-lateralized emotional responsivity to negative stimuli may be uniquely associated with depression.

Citing Articles

Exploring brain activity for positive and negative emotions by means of EEG microstates.

Prete G, Croce P, Zappasodi F, Tommasi L, Capotosto P Sci Rep. 2022; 12(1):3404.

PMID: 35233057 PMC: 8888606. DOI: 10.1038/s41598-022-07403-0.

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