Exosomal MicroRNAs in Cancer-related Sarcopenia: Tumor-derived Exosomal MicroRNAs in Muscle Atrophy

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2021 Feb 8

PMID 33554647

Citations 5

Authors

Chenyuan Li

Qi Wu

Zhiyu Li

Zhong Wang

Yi Tu

Chuang Chen

Si Sun

Shengrong Sun

Affiliations

Soon will be listed here.

Abstract

Cancer-associated sarcopenia is a complex metabolic syndrome marked by muscle mass wasting. Muscle wasting is a serious complication that is a primary contributor to cancer-related mortality. The underlying molecular mechanisms of cancer-associated sarcopenia have not been completely described to date. In general, evidence shows that the main pathophysiological alterations in sarcopenia are associated with the degradation of cellular components, an exceptional inflammatory secretome and mitochondrial dysfunction. Importantly, we highlight the prospect that several miRNAs carried by tumor-derived exosomes that have shown the ability to promote inflammatory secretion, activate catabolism, and even participate in the regulation of cellular degradation pathways can be delivered to and exert effects on muscle cells. In this review, we aim to describe the current knowledge about the functions of exosomal miRNAs in the induction of cancer-associated muscle wasting and propose potential treatment strategies.

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References

Zhang L, Pan J, Dong Y, Tweardy D, Dong Y, Garibotto G . Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013; 18(3):368-79. PMC: 3794464. DOI: 10.1016/j.cmet.2013.07.012. View

Grimolizzi F, Monaco F, Leoni F, Bracci M, Staffolani S, Bersaglieri C . Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression. Sci Rep. 2017; 7(1):15277. PMC: 5681649. DOI: 10.1038/s41598-017-15475-6. View

Kir S, White J, Kleiner S, Kazak L, Cohen P, Baracos V . Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 2014; 513(7516):100-4. PMC: 4224962. DOI: 10.1038/nature13528. View

Argiles J, Lopez-Soriano F, Busquets S . Mediators of cachexia in cancer patients. Nutrition. 2019; 66:11-15. DOI: 10.1016/j.nut.2019.03.012. View

Tomasetti M, Monaco F, Manzella N, Rohlena J, Rohlenova K, Staffolani S . MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma. Oncotarget. 2016; 7(24):36338-36352. PMC: 5095004. DOI: 10.18632/oncotarget.8916. View

Robbins P, Morelli A . Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014; 14(3):195-208. PMC: 4350779. DOI: 10.1038/nri3622. View

Rivas D, Lessard S, Rice N, Lustgarten M, So K, Goodyear L . Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. FASEB J. 2014; 28(9):4133-47. PMC: 5058318. DOI: 10.1096/fj.14-254490. View

Thissen J, Loumaye A . [Role of Activin A and Myostatin in cancer cachexia]. Ann Endocrinol (Paris). 2013; 74(2):79-81. DOI: 10.1016/j.ando.2013.03.004. View

Bodine S, Furlow J . Glucocorticoids and Skeletal Muscle. Adv Exp Med Biol. 2015; 872:145-76. DOI: 10.1007/978-1-4939-2895-8_7. View

10.

Penna F, Bonetto A, Muscaritoli M, Costamagna D, Minero V, Bonelli G . Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?. Int J Cancer. 2009; 127(7):1706-17. DOI: 10.1002/ijc.25146. View

11.

He W, Calore F, Londhe P, Canella A, Guttridge D, Croce C . Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci U S A. 2014; 111(12):4525-9. PMC: 3970508. DOI: 10.1073/pnas.1402714111. View

12.

Lee S . Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS One. 2008; 3(2):e1628. PMC: 2237902. DOI: 10.1371/journal.pone.0001628. View

13.

Fontes-Oliveira C, Busquets S, Toledo M, Penna F, Aylwin M, Sirisi S . Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency?. Biochim Biophys Acta. 2012; 1830(3):2770-8. DOI: 10.1016/j.bbagen.2012.11.009. View

14.

Cai D, Frantz J, Tawa Jr N, Melendez P, Oh B, Lidov H . IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004; 119(2):285-98. DOI: 10.1016/j.cell.2004.09.027. View

15.

Antunes D, Padrao A, Maciel E, Santinha D, Oliveira P, Vitorino R . Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting. Biochim Biophys Acta. 2014; 1841(6):896-905. DOI: 10.1016/j.bbalip.2014.03.004. View

16.

Scicchitano B, Faraldi M, Musaro A . The Proteolytic Systems of Muscle Wasting. Recent Adv DNA Gene Seq. 2015; 9(1):26-35. DOI: 10.2174/2352092209999150911121502. View

17.

Zhang Y, Wang J, Wang X, Gao T, Tian H, Zhou D . The autophagic-lysosomal and ubiquitin proteasome systems are simultaneously activated in the skeletal muscle of gastric cancer patients with cachexia. Am J Clin Nutr. 2020; 111(3):570-579. DOI: 10.1093/ajcn/nqz347. View

18.

Borja-Gonzalez M, Casas-Martinez J, McDonagh B, Goljanek-Whysall K . Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. Antioxidants (Basel). 2020; 9(4). PMC: 7222422. DOI: 10.3390/antiox9040345. View

19.

Clapham J, Arch J, Chapman H, Haynes A, Lister C, Moore G . Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature. 2000; 406(6794):415-8. DOI: 10.1038/35019082. View

20.

Bossola M, Muscaritoli M, Costelli P, Grieco G, Bonelli G, Pacelli F . Increased muscle proteasome activity correlates with disease severity in gastric cancer patients. Ann Surg. 2003; 237(3):384-9. PMC: 1514311. DOI: 10.1097/01.SLA.0000055225.96357.71. View