P53 Orchestrates a Complex Symphony of Cellular Processes During Oncosuppression
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Abstract
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the (tumor protein p53) gene is so prevalent in human cancers.
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