Comparison of the Ductal Carcinoma in Situ Between White Americans and Chinese Americans

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2021 Feb 6

PMID 33546026

Authors

Xin-Wen Kuang

Zhi-Hong Sun

Jun-Long Song

Zhanyong Zhu

Chuang Chen

Affiliations

Soon will be listed here.

Abstract

Currently, the wide-spread use of screening mammography has led to dramatic increases in ductal carcinoma in situ (DCIS). However, DCIS of Chinese Americans, the largest Asian subgroup in American, has rarely been comprehensively studied over the past decade. This work compared the DCIS characteristics and prognosis of Chinese American patients with White Americans in the USA to determine the characteristics and prognosis of DCIS patients of Chinese Americans.The data were obtained using the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data. The diagnosis and treatment variables between the two groups were compared by means of Chi-square tests. Survival was determined with the use of the Kaplan-Meier method and the multivariable Cox proportional hazard regression model.From 1975 to 2016, 81,745 White Americans and 2069 Chinese Americans were diagnosed with ductal carcinoma in situ. Compared with the white patients, the Chinese Americans were younger (P < .001) with smaller tumors (P < .001) and higher family income (P < .001). DCIS patients of Chinese American group accounted for a higher percentage of all breast cancers than the whites (P < .001). In the multivariable Cox proportional hazard regression analysis, Chinese American was an independent favorable prognostic factor in terms of overall survival (OS) (HR, 0.684; 95% CI, 0.593-0.789; P < .001) compared with the white group.In conclusion, DCIS characteristics of the Chinese group, which exhibited a higher proportion of younger age, a higher DCIS ratio, and a better prognosis, were distinct from those of the White Americans.

References

Kummerow K, Du L, Penson D, Shyr Y, Hooks M . Nationwide trends in mastectomy for early-stage breast cancer. JAMA Surg. 2014; 150(1):9-16. DOI: 10.1001/jamasurg.2014.2895. View

Chen D, Song C, Ouyang Q, Jiang Y, Ye F, Ma F . Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US. Oncotarget. 2015; 6(14):12774-82. PMC: 4494973. DOI: 10.18632/oncotarget.3666. View

DeSantis C, Ma J, Gaudet M, Newman L, Miller K, Sauer A . Breast cancer statistics, 2019. CA Cancer J Clin. 2019; 69(6):438-451. DOI: 10.3322/caac.21583. View

Chow W, Shuch B, Linehan W, Devesa S . Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics. Cancer. 2012; 119(2):388-94. PMC: 3538913. DOI: 10.1002/cncr.27690. View

Zhu S, Chen X, Wu J, Huang O, He J, Zhu L . [Surgical treatment and prognosis of ductal carcinoma in situ: 526 cases analysis]. Zhonghua Wai Ke Za Zhi. 2017; 55(2):114-119. DOI: 10.3760/cma.j.issn.0529-5815.2017.02.008. View

Hofvind S, Sorum R, Haldorsen T, Langmark F . [Incidence of breast cancer before and after implementation of mammography screening]. Tidsskr Nor Laegeforen. 2006; 126(22):2935-8. View

Huang N, Liu M, Chen J, Yang B, Xue J, Quan C . Surgical management of breast cancer in China: A 15-year single-center retrospective study of 18,502 patients. Medicine (Baltimore). 2016; 95(45):e4201. PMC: 5106045. DOI: 10.1097/MD.0000000000004201. View

Jonsson H, Johansson R, Lenner P . Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden. Int J Cancer. 2005; 117(5):842-7. DOI: 10.1002/ijc.21228. View

Yuan X, Wang N, Ouyang T, Yang L, Song M, Lin B . Current status of diagnosis and treatment of primary breast cancer in beijing, 2008. Chin J Cancer Res. 2013; 23(1):38-42. PMC: 3587532. DOI: 10.1007/s11670-011-0038-y. View

10.

Hofvind S, Vacek P, Skelly J, Weaver D, Geller B . Comparing screening mammography for early breast cancer detection in Vermont and Norway. J Natl Cancer Inst. 2008; 100(15):1082-91. PMC: 2720695. DOI: 10.1093/jnci/djn224. View

11.

Wang L, Zhang W, Lyu S, Liu X, Zhang T, Liu S . Clinicopathologic characteristics and molecular subtypes of microinvasive carcinoma of the breast. Tumour Biol. 2015; 36(4):2241-8. DOI: 10.1007/s13277-014-2652-z. View

12.

Bremer T, Whitworth P, Patel R, Savala J, Barry T, Lyle S . A Biological Signature for Breast Ductal Carcinoma to Predict Radiotherapy Benefit and Assess Recurrence Risk. Clin Cancer Res. 2018; 24(23):5895-5901. DOI: 10.1158/1078-0432.CCR-18-0842. View

13.

Yao J, Zhan W, Chen M, Zhang X, Zhu Y, Fei X . Sonographic Features of Ductal Carcinoma In Situ of the Breast With Microinvasion: Correlation With Clinicopathologic Findings and Biomarkers. J Ultrasound Med. 2015; 34(10):1761-8. DOI: 10.7863/ultra.15.14.07059. View

14.

Anderson C, Islam J, Elizabeth Hodgson M, Sabatino S, Rodriguez J, Lee C . Long-Term Satisfaction and Body Image After Contralateral Prophylactic Mastectomy. Ann Surg Oncol. 2017; 24(6):1499-1506. PMC: 5472420. DOI: 10.1245/s10434-016-5753-7. View

15.

de Boniface J, Frisell J, Bergkvist L, Andersson Y . Breast-conserving surgery followed by whole-breast irradiation offers survival benefits over mastectomy without irradiation. Br J Surg. 2018; 105(12):1607-1614. PMC: 6220856. DOI: 10.1002/bjs.10889. View

16.

Johnson A, Shekhdar J . Breast cancer incidence: what do the figures mean?. J Eval Clin Pract. 2005; 11(1):27-31. DOI: 10.1111/j.1365-2753.2004.00491.x. View

17.

Siegel R, Miller K, Jemal A . Cancer statistics, 2018. CA Cancer J Clin. 2018; 68(1):7-30. DOI: 10.3322/caac.21442. View

18.

Kong Y, Yang L, Tang H, Lv N, Xie X, Li J . A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008. PLoS One. 2013; 8(11):e81055. PMC: 3835770. DOI: 10.1371/journal.pone.0081055. View

19.

Fisher S, Gao H, Yasui Y, Dabbs K, Winget M . Survival in stage I-III breast cancer patients by surgical treatment in a publicly funded health care system. Ann Oncol. 2015; 26(6):1161-1169. PMC: 4516043. DOI: 10.1093/annonc/mdv107. View

20.

Ward E, DeSantis C, Lin C, Kramer J, Jemal A, Kohler B . Cancer statistics: Breast cancer in situ. CA Cancer J Clin. 2015; 65(6):481-95. DOI: 10.3322/caac.21321. View