[Screening for Bilateral Vestibulopathy in Outpatients with Unsteadiness]

This study aimed to find bilateral vestibulopathy（BVP） patients in outpatients with unsteadiness and investigate their clinical characteristics. According to the common manifestation and etiologies of BVP, 2075 outpatients who were diagnosed as imbalance, follow up on chemotherapy, bilateral Menière's disease, systemic lupus erythematosus（SLE） and vasculitis from January 2018 to October 2019 were searched based on the hospital information system. After completing a telephone screening interview, eligible individuals whose symptoms were in consistent with the diagnostic criteria of BVP were scheduled for questionnaires and video head impulse test（vHIT）. A total of 131 patients replied and complained chronic unsteadiness. The response rates of patients with bilateral Menière's disease, chemotherapy, SLE and vasculitis were 10.0%, 0%, 0.3% and 1.2%, respectively. Unsteadiness is uncommon or mild in outpatients with vasculitis, SLE and chemotherapy. Twenty-nine patients presented with typical symptoms of BVP and only 3 were diagnosed as BVP after vHIT. The horizontal vHIT gain was significantly lower among patients who reported very severe life impact than those reported mild to severe impact in older patients, as well as in male patients（both <0.01）. However, no significant differences were noted in younger and female patients（=0.396, 0.180, respectively）. BVP accounts for 2.3% in outpatients with unsteadiness, and only 10.3% of patients who presents with typical symptoms meet the diagnostic criteria, suggesting vestibular function test is of great significance in making diagnosis.