Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium
Overview
Chemistry
Molecular Biology
Affiliations
Heart failure remains the most common cause of death in the industrialized world. In spite of new therapeutic interventions that are constantly being developed, it is still not possible to completely protect against heart failure development and progression. This shows how much more research is necessary to understand the underlying mechanisms of this process. In this review, we give a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression. In particular, we focus on the regulation of fatty acid metabolism and the effects of fatty acid accumulation on mitochondrial structural and functional homeostasis.
Geng J, Zhang X, Wang Y, Guo D, Liu P, Pu S Int J Med Sci. 2025; 22(5):1223-1236.
PMID: 40027179 PMC: 11866539. DOI: 10.7150/ijms.107224.
Martinez C, Zheng A, Xiao Q Antioxidants (Basel). 2024; 13(11).
PMID: 39594472 PMC: 11591317. DOI: 10.3390/antiox13111330.
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure.
Sharma G, Chaurasia S, Carlson M, Mishra P Am J Physiol Heart Circ Physiol. 2024; 327(6):H1327-H1342.
PMID: 39453429 PMC: 11684949. DOI: 10.1152/ajpheart.00539.2024.
Nakamura E, Aoki T, Endo Y, Kazmi J, Hagiwara J, Kuschner C Life (Basel). 2024; 14(4).
PMID: 38672748 PMC: 11050834. DOI: 10.3390/life14040477.
Mann V, Sundaresan A, Shishodia S Biology (Basel). 2024; 13(4).
PMID: 38666853 PMC: 11048223. DOI: 10.3390/biology13040241.