Neuroimmune Response Mediated by Cytokines in Natural Scrapie After Chronic Dexamethasone Treatment

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2021 Feb 5

PMID 33540568

Citations 3

Authors

Isabel M Guijarro

Moises Garces

Pol Andres-Benito

Belen Marin

Alicia Otero

Tomas Barrio

Margarita Carmona

Isidro Ferrer

Juan J Badiola

Marta Monzon

Affiliations

Soon will be listed here.

Abstract

The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.

Citing Articles

5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues.

Hernaiz A, Sentre S, Betancor M, Lopez-Perez O, Salinas-Pena M, Zaragoza P Int J Mol Sci. 2023; 24(2).

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Bioinformatics and System Biology Techniques to Determine Biomolecular Signatures and Pathways of Prion Disorder.

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The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders.

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